Detail of "6340-79-0"

Reference

Preparation of 3-naphthyl-3-(carboxyalkylthio)alkanoates and analogs as leukotriene antagonists

Preparation of 3-naphthyl-3-(carboxyalkylthio)alkanoates and analogs as leukotriene antagonists. Frazee, James Simpson; Gleason, John Gerald; Hall, Ralph Floyd; Uzinskas, Irene Nijole (SmithKline Beecham Corp., USA). PCT Int. Appl. WO 9117149 A1 14 Nov 1991, 30 pp. DESIGNATED STATES: W: AU, CA, JP, KR, US; RW: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE. 6340-79-0 and 139160-20-6 are cas registry numbers. These chemicals are also mentioned in this article. (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D257-04. ICS: C07C057-40; A61K031-41; A61K031-10. APPLICATION: WO 91-US2889 26 Apr 1991. PRIORITY: US 90-518583 1 May 1990. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Section cross-reference(s): 1 Title compds. [I; R = (CH2)nA, (CH2)nAr; A = R2, 5-tetrazolyl, etc.; Ar = aryl; R1 = (phenyl)alkyl, (phenyl)alkoxy, alkylthio, alkynyl, etc.; R2 = CO2R4, N(R5)2, etc.; R4 = H, pharmaceutically acceptable ester residue or cation; R5 = H, (phenyl)alkyl, etc.; Y = R2, CHR3(CH2)mR2, 5-tetrazolyl, etc.; R3 = H, Me, alkoxy, F, OH; Z = O, SOq; m, q = 0-2; n = 0-6] were prepd. as leukotriene antagonists (no data). Thus, 4-BrC6H4COCH2CH2CO2H was converted in 9 steps to 7-(5-phenylpentyl)-1-naphthaldehyde which was condensed with Ph3P:CHCO2CMe3 and the product condensed with HSCH2CH2CO2Me to give, after sapon., title compd. II. .