Detail of "63425-00-3"

CAS Number:
63425-00-3
Name:
Pyrido[3',4':4,5]cyclohept[1,2-b]indol-6(2H)-one,4-ethylidene-1,3,4,4a,5,7,12,12a-octahydro-2-methyl-, (4E,4aR,12aS)-
Molecular Structure:
Formula:
C19H22 N2 O
Molecular Weight:
294.3908
Synonyms:
Pyrido[3',4':4,5]cyclohept[1,2-b]indol-6(2H)-one,4-ethylidene-1,3,4,4a,5,7,12,12a-octahydro-2-methyl-, [4aR-(4E,4aa,12aa)]-; Methuenine
Density:
1.21g/cm³
Boiling Point:
479.9°Cat760mmHg
Flash Point:
244°C

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Effect of methuenine on the fast inward sodium current in frog atrial fibers: Effect of methuenine on the fast inward sodium current in frog atrial fibers. Sauviat, Martin Pierre (Cent. Orsay, Univ. Paris XI, Orsay 91405, Fr.). Zhongguo Yaoli Xuebao, 5(2), 92-7 (English) 1984. CODEN: CYLPDN. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effect of methuenine (I) [63425-00-3] on action potential and fast inward Na+ current of frog atrial fibers was studied. At 13 mM, methuenine blocked the action potential without altering the resting membrane potential. Methuenine inhibited the fast Na+ conductance without changing the selectivity of the Na+ channel. The kinetic parameters of the Na+ current were not markedly shifted. The steady state inactivation curve was only slightly shifted towards more neg. membrane potentials. The inhibition of the Na+ conductance by methuenine was frequency-dependent. The effect of methuenine on Na current was slightly different from the effect of ervatamine. Methuenine might be effective in the control of cardiac arrhythmias since the drug mainly decreased the excitability of depolarized fibers.