Detail of "6346-05-0"

Reference

Synthesis and identification of the major metabolites of prazosin formed in dog and rat

Synthesis and identification of the major metabolites of prazosin formed in dog and rat. Althuis, T. H.; Hess, H. J. (Med. Res. 60547-93-5 and 6346-05-0 are cas registry numbers. These chemicals are also mentioned in this article. Lab., Pfizer, Inc., Groton, Conn., USA). J. Med. Chem., 20(1), 146-9 (English) 1976. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 28 The 6-O-demethyl (I-H2SO4) [60548-10-9] and 7-O-demethyl (II-H2SO4) [60548-11-0] analogs of prazosin-HCl (III-HCl) [19237-84-4] were prepd. and I and II were found to be identical with major and significant metabolites of III in dogs and rats, but had less potent blood pressure lowering activity than III in dogs. I and II were prepd. from isovanillin [621-59-0] and vanillin [121-33-5], resp., in 10-step reaction sequences. Two minor metabolites of III, 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline-2HCl [60548-08-5] and 2,4-diamino-6,7-dimethoxyquinazoline [60547-96-8] were prepd. and detd. to have low hypotensive activity. .

Protoberberine alkaloids

Protoberberine alkaloids. Synthesis of 3,9-dihydroxy-2,10-dimethoxytetrahydroprotoberberine and 3,11-dihydroxy-2,10-dimethoxytetrahydropseudoberberine. Chiang, Hsuch-Ching; Brochmann-Hanssen, Einar (Sch. Pharm., Natl.There are some reagents with their cas registry numbers 5487-33-2 and 6346-05-0 are used in this study. Taiwan Univ., Taipei, Taiwan). T'ai-wan Yao Hsueh Tsa Chih, 27(1-2), 90-7 (English) 1975. CODEN: JTPHAO. DOCUMENT TYPE: Journal CA Section: 31 (Alkaloids) Section cross-reference(s): 27 The title compds. I (R = OH, R1 = H; R = H, R1 = OH) were prepd. from 4,3-MeO(PhCH2O)C6H3CHO via 4,3-MeO(PhCH2O)C6H3CH2CH2NHCOCH2C6H3(OCH2Ph)OMe-3, 4 and the isoquinoline II. .