Reference

Evaluation of the teratogenic potential of the oxidative dyes 6-chloro-4-nitro-2-aminophenol and o-chloro-p-phenylenediamine

Evaluation of the teratogenic potential of the oxidative dyes 6-chloro-4-nitro-2-aminophenol and o-chloro-p-phenylenediamine. Picciano, J. C.; Morris, W. E.; Wolf, B. A. (Revlon Res. Cent., Bronx, NY 10473, USA). Food Chem. Toxicol.In this article, certain chemicals are used. Some of their cas registry numbers are 615-66-7 and 6358-09-4 , 22(2), 147-9 (English) 1984. CODEN: FCTOD7. ISSN: 0278-6915. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) 6-Chloro-4-nitro-2-aminophenol (I) [6358-09-4] and o-chloro-p-phenylenediamine (II) [615-66-7] were administered by gavage to rats on days 6-15 of gestation at dose levels of 87.5, 175 and 350 mg I/kg/day and 100, 200 and 400 mg II/kg/day. Maternal body-wt. gain was reduced by the high dose of each dye and the intermediate dose of II. Rats given the high dose of II showed an increase in resorptions and a decrease in fetal body wts. No embryotoxic or fetotoxic effects were obsd. with I. Evaluation of fetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle-control groups but showed an increase in the incidence of abnormal fetuses in the group exposed to vitamin A, the pos. control. .