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637-32-1

Basic Information
CAS No.: 637-32-1
Name: PROGUANIL HYDROCHLORIDE
Molecular Structure:
Molecular Structure of 637-32-1 (PROGUANIL HYDROCHLORIDE)
Formula: C11H16 Cl N5 . Cl H
Molecular Weight: 290.195
Synonyms: Biguanide,1-(p-chlorophenyl)-5-isopropyl-, monohydrochloride (8CI); Imidodicarbonimidicdiamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, monohydrochloride (9CI);1-(p-Chlorophenyl)-5-isopropylbiguanide hydrochloride; 3359 RP; Chloroguanidehydrochloride; Chloroquanil; Diguanyl; Drinupal; Drinupal hydrochloride; Guanatol;Guanatol hydrochloride; M 4888; Paludrine; Paludrine hydrochloride; Palusil;Palusil hydrochloride; Proguanil hydrochloride; RP 3359; SN 12,837; SN 12837;Tirian; Tirian hydrochloride
Melting Point: 249-2510C
Boiling Point: 402.7oC at 760 mmHg
Flash Point: 197.4oC
Hazard Symbols: T
Risk Codes: 25
Safety: Poison by ingestion and intravenous routes. Experimental reproductive effects. An antimalarial drug. When heated to decomposition it emits very toxic fumes of Cl and NOx.
PSA: 83.79000
LogP: 4.06530
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  • PROGUANIL HYDROCHLORIDE

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    637-32-1

    PROGUANIL HYDROCHLORIDE

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  • 1-(p-CHLOROPHENYL)-5-ISOPROPYLBI GUANIDE HYDROCHLORIDE

  • Casno:

    637-32-1

    1-(p-CHLOROPHENYL)-5-ISOPROPYLBI GUANIDE HYDROCHLORIDE

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    637-32-1 Imidodicarbonimidicdiamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, hydrochloride (1:1) C11H16CLN5.CLH

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Chemistry

IUPAC Name: (1E)-1-[Amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine hydrochloride
The MF of Proguanil hydrochloride (CAS NO.637-32-1) is C11H17Cl2N5.

                       
The MW of Proguanil hydrochloride (CAS NO.637-32-1) is 290.19.
Synonyms of Proguanil hydrochloride (CAS NO.637-32-1): Biguanide, 1- (p-chlorophenyl)-5-isopropyl-, monohydrochloride ; Palusil (hydrochloride) ; Diguanyl (hydrochloride)
Product Categories: Aromatics;Bases & Related Reagents;Intermediates & Fine Chemicals
Flash Point: 197.4 °C
Boiling Point: 402.7 °C
Melting Point: 249-251 °C
Apperance: White Solid
EINECS: 211-283-7

Uses

  Proguanil hydrochloride (CAS NO.637-32-1) is used as antimalarial.

Toxicity Data With Reference

1.    

orl-rat LD50:58 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
2.    

ivn-rat LD50:33 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
3.    

orl-mus LD50:27 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
4.    

ivn-mus LD50:23 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
5.    

orl-rbt LD50:172 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 2 (1947),181.
6.    

ivn-rbt LD50:44,850 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
7.    

ivn-gpg LD50:39,510 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
8.    

orl-ckn LD50:400 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 2 (1947),181.

Safety Profile

Poison by ingestion and intravenous routes. Experimental reproductive effects. An antimalarial drug. When heated to decomposition it emits very toxic fumes of Cl and NOx.Safety information of Proguanil hydrochloride (CAS NO.637-32-1):
RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III