Reference

Gas chromatographic and mass spectrometric studies on metabolites of amino adamantane excreted in urine

Gas chromatographic and mass spectrometric studies on metabolites of amino adamantane excreted in urine. Wesemann, W.; Schollmeyer, J. D.; Sturm, G. (Inst. Physiol. Chem. II, Philipps-Univ., Marburg, Ger.). Arzneim.-Forsch., 27(7), 1471-7 (German) 1977. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Amantadine-HCl (I-HCl) [665-66-7] and D-145-HCl (II-HCl) [41100-52-1] administered either i.p. or orally to rats at 50-100 mg/kg were rapidly absorbed. Between 20 and 25% I and 6-11% II were excreted unchanged in the urine, this excretion being max. 2 h after administration. 1-Amino-3-hydroxyadamantane [702-82-9] was the only I metabolite detected, whereas 1-hydroxy-3,5-dimethyladamantane [707-37-9], 1-amino-3-hydroxymethyl-5-methyladamantane [58850-55-8], 1-amino-4-hydroxy-3,5-dimethyladamantane [58850-54-7], and 1-amino-7-hydroxy-3,5-dimethyladamantane [63971-25-5] were II metabolites. Following oral administration of 10 mg II to a human volunteer, I and 1-amino-3-hydroxymethyl-5-methyladamantane were excreted in the urine.