Detail of "64218-02-6"

Reference

Stimulation of prostaglandin production by (2E,6Z,10E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetr aen-1-ol (plaunotol), a new antiulcer drug, in vitro and in vivo

Stimulation of prostaglandin production by (2E,6Z,10E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetr aen-1-ol (plaunotol), a new antiulcer drug, in vitro and in vivo. Ushiyama, Shigeru; Matsuda, Keiichi; Asai, Fumitoshi; Yamazaki, Mitsuo (Biol. Res.Several substances are used for example 363-24-6 and 35121-78-9 which are their cas registry numbers. Lab., Sankyo Co., Ltd., Tokyo 140, Japan). Biochem. Pharmacol., 36(3), 369-75 (English) 1987. CODEN: BCPCA6. ISSN: 0006-2952. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In cultured cells of 3T6 fibroblasts, plaunotol [64218-02-6] and its main metabolite 1-carboxylic-plaunotol [65811-39-4] at concns. of 10-100 mM increased PGE2 [363-24-6] and PGI2 [35121-78-9] prodn. 2-4-fold. These compds. increased the release of radioactive arachidonic acid from [14C]arachidonic acid prelabeled 3T6 fibroblast cells 2-fold at 30 mM, and this increase was inhibited by addn. of mepacrine, a phospholipase [9013-93-8] inhibitor. Plaunotol and its main metabolite had no effect on prostaglandin (PG) cyclooxygenase activity. These results indicate that plaunotol and its main metabolite stimulate PG prodn. by activating cellular phospholipase. In gastric-mucosa slices, PGE2 and PGI2 prodn. was increased either by oral administration of plaunotol to rats at a dose of 300 mg/kg or by addn. of the main metabolite to the incubation medium. These results suggest that plaunotol increases the PG levels in gastric mucosa by stimulating the PG biosynthesis, particularly the cellular phospholipase activity. The increased levels of PG may participate in the anti-ulcer activity of plaunotol. .

Diterpene alcohol from croton-plants

Diterpene alcohol from croton-plants. Mishima, Hiroshi; Ogiso, Akira; Kobayashi, Shinsaku (Sankyo Co., Ltd., Japan). Japan. Kokai JP 52070010 10 Jun 1977 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-045. APPLICATION: JP 75-145597 5 Dec 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 62 The diterpene alc. (I) [64218-02-6], a drug for digestive tract ulcer treatment, was prepd. from C. columnarnis plants. Thus, 28 kg crushed plau-noi was extd. with MeOH 3 times under reflux to give 117 g oily substance, which was purified on a 1.5 kg silica gel column by eluting with 30% EtOAc-contg. benzene to give 17 g I. I is more effective in reserpine- or cysteamine-induced ulcer treatment than Gefarnate.