Detail of "64241-34-5"

CAS Number:
64241-34-5
Name:
Hydrazinecarboxylicacid, 2-[6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]-, ethyl ester
Molecular Structure:
Formula:
C12H21 N5 O3
Molecular Weight:
283.38
Synonyms:
CGP 18684E;Cadral; Cadralazine; Cadraten; Cadrilan; DC 826; ISF 2469; Presmode
Density:
1.253 g/cm³
Safety:
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x. Details

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Other names:Cadral , Cadraten , Cadrilan Systematic name:ethoxy-N'-{6-[ethyl(2-hydroxypropyl)amino]pyridazin-3-yl}carbohydrazide

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HYDRAZINECARBOXYLIC ACID, 2-[6-[ETHYL(2-HYDROXYPROPYL)AMINO]-3-PYRIDAZINYL]-, ETHYL ESTER

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TLC photodensitometry in stability studies of cadralazine: TLC photodensitometry in stability studies of cadralazine. Crolla, T.; Citerio, L.; Visconti, M.; Pifferi, G. (Lab. Biomed. Res., ISF, Trezzano 20090, Italy). HRC CC, J. High Resolut. Chromatogr. Chromatogr. Commun., 6(8), 445-7 (English) 1983. CODEN: HCJCDB. ISSN: 0344-7138. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Cadralazine [64241-34-5] and 3-(2-hydroxypropyl)ethylaminopyridazine [79157-64-5] were detd. by sepn. on silica gel plates with CHCl3-MeOH-H2O (:1) and 3,4,5-trimethoxythiobenzoyl-(4-methyl)piperazine as internal std. A mobile phase of THF-MeOH () and L-a-(3,4,5-trimethoxythiobenzoyl)caprolactam internal std. were used for detn. of 6-(2-hydroxypropyl)ethylaminopyridazin-3-one [79157-63-4] and 6-[(2-hydroxypropyl)ethylamino]-1,2,4-triazolo[4,3-b]pyridazin-3-one [70887-22-8]. The spots were detected by fluorescence quenching at 254 nm. The precision for cadralazine was ~1.8%, and the error was <2. 79157-63-4 and 79157-64-5 are just another two chemicals used in this study.73%, satisfactory for degrdn. studies. .

Multiple inverse isotope dilution assay for cadralazine and four metabolites in biological fluids: Multiple inverse isotope dilution assay for cadralazine and four metabolites in biological fluids. Schuetz, H.; Faigle, J. W. (Res. Dev. Dep., Ciba-Geigy Ltd., Basle CH-4002, Switz.). J. Chromatogr., 281, 273-80 (English) 1983. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) An inverse isotope diln. assay was developed for the specific detn. of 14C-labeled cadralazine (I) [64241-34-5] and 4 of its metabolites in biol. samples. After addn. of unlabeled carrier substances to the sample, a metabolite, II [70887-18-2], was derivatized. The deriv. and the unaltered compds. (I and the other metabolites III [70887-26-2], IV [70887-22-8], and V [65919-92-8]) were extd. and sepd. by high-performance liq. chromatog. on silica gel. Quantitation was performed by on-line UV detection at 274 nm and off-line radiometry by liq. scintillation counting. 64241-34-5 which is the cas registry number of some chemical is mentioned. Endogenous compds. and unknown metabolites did not interfere in the assay. The anal. of water, plasma, and urine samples spiked with [14C]cadralazine showed mean recoveries between 98.4 and 101.3%. The lower limit of detection was 10 nmol/L (3 ng/mL) for any of the compds. I-V. The method was used for the anal. of plasma and urine samples of rats dosed with [14C]cadralazine. .