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CAS No.: | 64248-60-8 |
---|---|
Name: | 2,6-Difluorobenzotrifluoride |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C7H3F5 |
Molecular Weight: | 182.093 |
Synonyms: | 2,6-Difluorobenzotrifluoride; |
Density: | 1.386 g/cm3 |
Boiling Point: | 121 °C at 760 mmHg |
Flash Point: | 32.7 °C |
Hazard Symbols: | Xi |
PSA: | 0.00000 |
LogP: | 2.98360 |
3,5-dichloro-2,6-difluorobenzotrifluoride
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
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With sodium acetate In water; acetic acid |
2,6-difluoroaniline
trifluoromethylcopper(I)
A
1,3-Difluorobenzene
B
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Stage #1: 2,6-difluoroaniline With hydrogen fluoride; sodium nitrite In water; acetonitrile at 0℃; Inert atmosphere; Stage #2: trifluoromethylcopper(I) In water; N,N-dimethyl-formamide; acetonitrile at 0℃; for 0.25h; Inert atmosphere; Overall yield = 27 %Spectr.; |
piperazine
1,3-difluoro-2-(trifluoromethyl)benzene
1-(3-fluoro-2-(trifluoromethyl)phenyl)piperazine
Conditions | Yield |
---|---|
at 90℃; for 16h; | 73.4% |
carbon dioxide
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Stage #1: 1,3-difluoro-2-(trifluoromethyl)benzene With n-butyllithium In tetrahydrofuran; diethyl ether at -70 - -65℃; for 1h; Stage #2: carbon dioxide In tetrahydrofuran; diethyl ether at -65 - 30℃; for 5h; Stage #3: With hydrogenchloride In tetrahydrofuran; diethyl ether; water | 72% |
1,3-difluoro-2-(trifluoromethyl)benzene
(3-Fluoro-2-trifluoromethyl-phenyl)-hydrazine hydrochloride
Conditions | Yield |
---|---|
With hydrazine In dimethyl sulfoxide at 20℃; for 16h; | 67% |
1,3-difluoro-2-(trifluoromethyl)benzene
N,N-dimethyl-formamide
Conditions | Yield |
---|---|
Stage #1: 1,3-difluoro-2-(trifluoromethyl)benzene With n-butyllithium In tetrahydrofuran; cyclohexane at -70℃; for 0.5h; Inert atmosphere; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; cyclohexane at -70℃; for 2h; | 65% |
Conditions | Yield |
---|---|
With potassium phosphate In N,N-dimethyl-formamide at 135℃; for 72h; | 40% |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Stage #1: 1,3-difluoro-2-(trifluoromethyl)benzene With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Stage #2: 2,3-dihydroimidazo[1,2-c]quinazolin-9-ol In N,N-dimethyl-formamide; mineral oil at 20℃; | 37% |
1,3-difluoro-2-(trifluoromethyl)benzene
1,3-difluoro-4-nitro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid | |
With sulfuric acid; nitric acid In dichloromethane |
5-(benzyloxy)-3H-imidazo[4,5-b]pyridine
1,3-difluoro-2-(trifluoromethyl)benzene
5-(benzyloxy)-3-(3-fluoro-2-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridine
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 80℃; |
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The Benzene,1,3-difluoro-2-(trifluoromethyl)-, with the CAS registry number 64248-60-8, is also known as 2,6-Difluorobenzotrifluoride. This chemical's molecular formula is C7H3F5 and molecular weight is 182.0907. Its systematic name is called 1,3-difluoro-2-(trifluoromethyl)benzene. When you are using this chemical, please be cautious about it, it may cause inflammation to the skin or other mucous membranes.
Physical properties of Benzene,1,3-difluoro-2-(trifluoromethyl)-: (1)ACD/LogP: 2.98; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.98; (4)ACD/LogD (pH 7.4): 2.98; (5)ACD/BCF (pH 5.5): 107.8; (6)ACD/BCF (pH 7.4): 107.8; (7)ACD/KOC (pH 5.5): 992.12; (8)ACD/KOC (pH 7.4): 992.12; (9)Index of Refraction: 1.391; (10)Molar Refractivity: 31.22 cm3; (11)Molar Volume: 131.3 cm3; (12)Surface Tension: 20.2 dyne/cm; (13)Density: 1.386 g/cm3; (14)Flash Point: 32.7 °C; (15)Enthalpy of Vaporization: 34.43 kJ/mol; (16)Boiling Point: 121 °C at 760 mmHg; (17)Vapour Pressure: 17.8 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: FC(F)(F)c1c(F)cccc1F
(2)InChI: InChI=1/C7H3F5/c8-4-2-1-3-5(9)6(4)7(10,11)12/h1-3H
(3)InChIKey: NKKFHDNJRMWBFS-UHFFFAOYAK