Detail of "64285-06-9"

CAS Number:
64285-06-9
Name:
Ethanone,1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl-
Molecular Structure:
Formula:
C10H15 N O
Molecular Weight:
165.26
Synonyms:
Ethanone,1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-, (1R)-; 9-Azabicyclo[4.2.1]nonane,ethanone deriv.; (+)-Anatoxin a; (+)-Anatoxin a; (+)-Anatoxin-a; Anatoxin I; Anatoxin a; Anatoxin a
Density:
1.037 g/cm³
Boiling Point:
291 °C at 760 mmHg
Flash Point:
124.7 °C
Solubility:
Soluble to 50 mM in Water
Appearance:
Lyophilized Solid
Safety:
Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO_x. Details

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Action of anatoxin I at the neuromuscular junction: Action of anatoxin I at the neuromuscular junction. Biggs, D. F.; Dryden, W. F. (Fac. Pharm., Univ. Alberta, Edmonton, Alberta, Can.). Proc. West. Pharmacol. Soc., 20, 461-6 (English) 1977. CODEN: PWPSA8. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) In isolated frog sartorius muscle, anatoxin I (I) [64285-06-9] (10-8-10-6 M) caused graded depolarization of the end plate. I was 10-20-fold more potent than decamethonium in producing depolarization. The blocking action of I (10-7-10-8 M) was shown by decreased amplitude of the min. end plate potentials. In isolated chick embryo myoblast cultures I (9 ′ 10-8 - 1.8 ′ 10-6 M) caused depolarization followed by desensitization and a return to normal resting membrane potential in ~5 min. At a lower concn. (1.8 ′ 10-9-1.8 ′ 10-8 M) it caused a hyperpolarization which lasted for >5 min. When I and acetylcholine were applied simultaneously to the cells, I blocked the depolarizing action of acetylcholine. Thus, the toxin may produce its effects in whole animals by a combination of prolonged neuromuscular blockade and a decrease of the release of acetylcholine from the nerve terminal.

The total synthesis of anatoxin-a and loline: The total synthesis of anatoxin-a and loline. Meckler, Harold (State Univ. New York, Buffalo, NY, USA). 239 pp. Avail. Univ. Microfilms Int., Order No. DA8325087 From: Diss. Abstr. 25161-91-5 and 64285-06-9 which are cas registry numbers of substances are two of reagents here. Int. B 1984, 44(7), 2161 (English) 1983. DOCUMENT TYPE: Dissertation CA Section: 31 (Alkaloids) Abstract Unavailable .