Detail of "64485-90-1"

Reference

Preparation of 3-isoxazolidinylcephalosporins and orally administerable bactericides containing them

Preparation of 3-isoxazolidinylcephalosporins and orally administerable bactericides containing them. Takeuchi, Tomio; Kondo, Shinichi; Ikeda, Daishiro; Ko, Sehei (Microbiochemical Research Foundation, Japan). Jpn. Kokai Tokkyo Koho JP 03236392 A2 22 Oct 1991 Heisei, 9 pp. (Japan). CODEN: JKXXAF. CLASS: ICM: C07D501-24. ICS: A61K031-545. APPLICATION: JP 90-31390 14 Feb 1990. DOCUMENT TYPE: Patent CA Section: 26 (Biomolecules and Their Synthetic Analogs) Section cross-reference(s): 1 Orally administerable bactericides contain title compds. I [R1 = H, lower alkyl; R2 = CHR3O2CR4; R3 = H, lower alkyl; R4 = lower alkyl, lower alkoxy, cycloalkyloxy; stereochem. of the asterisk-marked C is (R), (S), or (RS)] or their pharmacol. acceptable salts as active ingredients. Esterification of 65 mg (6R,7R)-I [R1 = Me, R2 = Na, stereochem. of the asterisk-marked C is (S)] (prepn. given) with 40 mg pivaloyloxymethyl iodide in DMF at -15° for 30 min gave 5 mg corresponding pivaloyloxymethyl ester (II). 131528-21-7 and 64485-90-1 which are cas registry numbers of substances are two of reagents here. II at 300 mg was orally administered to mice to show 51.9% recovery (as free acid form) in urine. The free acid form showed strong and broad-spectrum antibacterial activity. .

Cephalosporin compounds

Cephalosporin compounds. Nagano, Noriaki; Nakano, Kohji; Shibanuma, Tadao; Murakami, Yukiyasu (Yamanouchi Pharmaceutical Co., Ltd. , Japan). U.S. US 4474779 A 2 Oct 1984, 37 pp. Cont.-in-part of U.S. Ser. No. 364,226, abandoned. (English). (United States of America). 64485-90-1 which is the cas registry number is also used here. CODEN: USXXAM. CLASS: IC: A61K031-545; C07D501-56. NCL: 424246000. APPLICATION: US 82-433247 7 Oct 1982. PRIORITY: JP 81-52408 9 Apr 1981; US 82-364226 1 Apr 1982. DOCUMENT TYPE: Patent CA Section: 26 (Biomolecules and Their Synthetic Analogs) Section cross-reference(s): 10 Cephalosporins I (R = carboxyalkyl; R1 = isothiazolylthiomethyl, iminoalkylidenedithietanyl) were prepd. Thus, 7-aminocephalosporanic acid was converted to the 3-iodomethyl deriv. and treated with the isothiazolethiol to give II which was acylated with blocked thiazoleacetic acid and treated with CF3CO2H to give III. III had a min. inhibitory concn. against Pseudomonas aeruginosa 99 of 0.Except for chemicals metioned above, 64485-90-1 is also used.78, mg/mL. ..