Reference

Pharmaceuticals containing adenosine carboxylic acid derivatives for thrombosis treatment

Pharmaceuticals containing adenosine carboxylic acid derivatives for thrombosis treatment. (Tanabe Seiyaku Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 58180424 A2 21 Oct 1983 Showa, 8 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-70. ICA: C07H019-16. APPLICATION: JP 82-62706 15 Apr 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 33 The adenosine-5'-carboxylic acid derivs. I [R1 = lower alkylamino, lower alkoxy or NHR2 (R2 = haloalkyl, aminoalkyl, hydroxyalkyl, formylalkyl, alkylaminoalkyl dialkoxyalkyl, aralkyl, hydroxyamino, alkylamino, phenylamino, halophenylamino)] or their pharmacol. permissive salts are effective in treatment of thrombosis. Tablets were prepd. contg. adenosine-5'-carboxylic acid N-(2-chloroethyl)amide (II) [88478-33-5] 7, D-mannitol 132, corn starch 54, hydroxypropyl cellulose 5 and Mg stearate 2 g. 645-36-3 and 65845-60-5 which are cas registry numbers of chemicals are mentioned. The min. i.v. ED of II in fibrinolysis in rats was 1 mg/kg. II was prepd. by the reaction of adenosine-5'-carboxylic acid [3415-09-6] with 2-chloroethylamine-HCl [870-24-6]. .

A highly convergent total synthesis of (+)-myxovirescine M2

A highly convergent total synthesis of (+)-myxovirescine M2. Seebach, Dieter; Maestro, Miguel A.; Sefkow, Michael; Neidlein, Axel; Sternfeld, Francine; Adam, Geo; Sommerfeld, Thimo (Lab. Org.Chemicals with cas numbers 90199-67-0 and 645-36-3 also play role. Chem., Eidg. Tech. Hochsch., Zurich CH-8092, Switz.). Helv. Chim. Acta, 74(8), 2112-18 (English) 1991. CODEN: HCACAV. ISSN: 0018-019X. DOCUMENT TYPE: Journal CA Section: 26 (Biomolecules and Their Synthetic Analogs) The antibiotic myxovirescine M2 (I) was synthesized from seven building blocks with the following chiral starting materials being employed: (S)-malic acid, (+)-D-ribonolactone, (S)-2-(hydroxymethyl)butanoate, and (2R,4S)-5-hydroxy-2,4-dimethylpentanoate. .