CAS No.645-43-2,GUANETHIDINE SULFATE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	645-43-2
Name:	GUANETHIDINE SULFATE

Formula:	C₁₀H₂₂N₄•H₂O₄S
Molecular Weight:	296.44
Synonyms:	2-(Octahydro-1-azocinyl)ethyl guanidine sulphate;Heptamethylenimine, 1-(2-guanidinoethyl)-;Guanethidine monosulfate [USAN];N-(2-Perhydroazocin-1-ylethyl)guanidine;Azocine, 1-((2-(aminoiminomethyl)amino)ethyl)octahydro-;(2-(Hexahydro-(2H)-azocin-1-yl)ethyl)guanidinium sulphate;Azocine, 1-(2-guanidinoethyl)octahydro-;Guanidine,[2-(hexahydro-1(2H)-azocinyl)- ethyl]-,sulfate (1:1);2-[2-(azocan-1-yl)ethyl]guanidine;Abapresin;Oktadin;Dopom;N-(2-Guanidino ethyl)heptamethylenimine sulfate;Eutensol;Esimil;Dopam;2-(1-N,N-Heptamethyleneimino)ethylguanidine;Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate (1:1);Guanethidinum [INN-Latin];Oktatenzin;Oktatensin;Ismelin(TN);Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-;Guanetidina [INN-Spanish];Octatensine;(2-(Hexahydro-1(2H)-azocinyl)ethyl) guanidine hydrogen sulfate;Sanotensin;2-[2-(azocan-1-yl)ethyl]guanidine; sulfuric acid;2-(1-Azacyclooctyl)ethylguanidine;Ismelin sulfate;Guanethidine sulfate;(2-(Octahydro-1-azocinyl)ethyl)guanidine;Ismelin;(2-(Hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate (1:1);
EINECS:	211-442-0
Melting Point:	276-281 °C
Boiling Point:	345.6 °C at 760 mmHg
Flash Point:	162.8 °C
Hazard Symbols:	Xn
Risk Codes:	R22
Safety:	S25;S36
PSA:	148.12000
LogP:	2.29240

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Chemistry

The molecular structure of Guanethidine Monosulfate (CAS NO.645-43-2) :

IUPAC Name: 2-[2-(azocan-1-yl)ethyl]guanidine; sulfuric acid
Empirical Formula: C₁₀H₂₄N₄O₄S
Molecular Weight: 296.387
EINECS: 211-442-0
H bond acceptors: 4
H bond donors: 4
Freely Rotating Bonds: 3
Polar Surface Area: 22.08Å²
Flash Point: 162.8 °C
Enthalpy of Vaporization: 58.97 kJ/mol
Boiling Point: 345.6 °C at 760 mmHg
Vapour Pressure: 6.09E-05 mmHg at 25°C
InChI
InChI=1/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)
Smiles
C1CCCCCCN1CCNC(=N)N.S(O)(O)(=O)=O
Classification Code: Antihypertensive; Drug / Therapeutic Agent; Skin / Eye Irritant

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	180mg/kg (180mg/kg)		Bollettino Chimico Farmaceutico. Vol. 111, Pg. 353, 1972.
mouse	LD50	intravenous	18500ug/kg (18.5mg/kg)		Bollettino Chimico Farmaceutico. Vol. 111, Pg. 353, 1972.
mouse	LD50	oral	1gm/kg (1000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Archiv der Pharmazie Vol. 321, Pg. 57, 1988.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. A human eye irritant. When heated to decomposition it emits very toxic fumes of SO_x and NO_x.
Hazard Codes: Harmful Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 25-36
S25:Avoid contact with eyes.
S36:Wear suitable protective clothing.
RTECS: MF3150000

Specification

Guanethidine monosulfate , with CAS number of 645-43-2, can be called Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate (1:1) ; Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)- ; 2-(1-N,N-Heptamethyleneimino)ethylguanidine ; 2-[2-(azocan-1-yl)ethyl]guanidine; sulfuric acid ; (2-(Octahydro-1-azocinyl)ethyl)guanidine ; (2-(Hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate (1:1) . It should be stored in tightly closed container at room temperature. Guanethidine monosulfate (CAS NO.645-43-2) can be used to treat moderate and severe hypertension and renal hypertension, including that secondary to pyelonephritis, renal amyloidosis and renal artery stenosis.