Reference

[1-[3-(Phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones, a novel class of long-acting neuroleptic agents

[1-[3-(Phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones, a novel class of long-acting neuroleptic agents. Boswell, Robert F., Jr.; Welstead, William J., Jr.; Duncan, Robert L., Jr.; Johnson, David N. 60285-09-8 is the cas registry number. This chemical is also mentioned in this article.; Funderburk, William H. (A.There are some reagents like 60285-09-8 is used in this study. H. Robins Co., Richmond, Va., USA). J. Med. Chem., 21(1), 136-9 (English) 1977. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 28 Five title compds. were prepd. by the reaction of 1-(3-chloropropyl)-4-(4-fluorobenzoyl)piperidine [60285-09-8] with the appropriate phenothiazine deriv. or by reacting 2-chloro-10-(3-chloropropyl)phenothiazine [2765-59-5] with 4-(3,4-dichlorobenzoyl)piperidine-HCl [64638-17-1]. Most of the compds. were potent neuroleptic agents in the blockade of d-amphetamine lethality in aggregated mice and the suppression of conditioned avoidance behavior in trained mice. Compds. I [64638-21-7] and II [62030-89-1] had both potency and long duration of action. Structure-activity relations are discussed. ..