Detail of "6469-93-8"

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Inhibition of conditional avoidance response by neuroleptics upon repeated administration

Inhibition of conditional avoidance response by neuroleptics upon repeated administration. Danneskiold-Samsoe, P.; Pedersen, V. (Dep. Pharmacol. Toxicol., H. Lundbeck and Co. A/S, Copenhagen, Den.). Psychopharmacology (Berlin), 51(1), 9-14 (English) 1976.Several reagents with their cas registry numbers 146-56-5 and 2413-38-9 are used here. CODEN: PSCHDL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Development of tolerance to neuroleptic compds. tested in the conditional avoidance model was investigated. Rats were pretreated approximately 2 weeks with daily oral doses of chlorprothixene-HCl [6469-93-8], (20 mg/kg), flupenthixol-2HCl [2413-38-9] (10 mg/kg), fluphenazine-2HCl [146-56-5] (2.5 mg/kg), or haloperidol [52-86-8] (10 mg/kg) or twice a week with piflutixol-HCl [61864-89-9] (0.31 mg/kg). Three days after withdrawal chlorprothixene and flupenthixol caused a slightly but significantly weaker inhibition of avoidance performance in rats pretreated with the respective compds. and compared with non-pretreated rats, the duration of effect was shortened. Six days after withdrawal of piflutixol the duration of effect of a dose of piflutixol causing max. inhibition was significantly shortened, while no homologous tolerance could be demonstrated in fluphenazine-pretreated rats. Cross tolerance was found after haloperidol-pretreatment when the rats were tested with fluphenazine 6 days after withdrawal. Homologous piflutixol tolerance could be shown 4 weeks after withdrawal. These results indicate that it is possible to demonstrate a slight tolerance to the effect of neuroleptic compds. when these are tested in conditional avoidance expts. The cause of this tolerance is discussed. .

Methods of detection and determination of neurotropic drugs in the blood of persons driving cars

Methods of detection and determination of neurotropic drugs in the blood of persons driving cars. Part IV. Detection and determination of thioxanthene derivatives (chlorprothixene, clorpenthixol). Kaniewska, Teresa (Zakl. Chem. Anal., Inst. Lekow, Warsaw, Pol.). Farm. Pol., 39(9), 531-5 (Polish) 1983. CODEN: FAPOA4. ISSN: 0014-8261. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Human blood was extd. with Et2O, which exts. the largest no. of neurotropic drugs that may affect driving, and extd. drugs were applied in 96% EtOH to TLC plates of silica gel 60 F254. The CHCl3-MeOH-C6H6-25% NH3 (:5:1) solvent system sepd. amitryptiline [50-48-6], opipramol [315-72-0], chlordiazepoxide [58-25-3] + nitrazepam [146-22-5], medazepam [2898-12-6], oxazepam [604-75-1], diazepam [439-14-5], imipramine [50-49-7], doxepine [1668-19-5], clorpenthixol-HCl (I) [27891-48-1] and chloprothixene-HCl (II) [6469-93-8]. For quant. detn. I was extd. from human blood with BuOAc at pH 9.0 and II with C6H14 at pH 8.0. I and II were detd. by gas chromatog. on OV-17 on Gas Chrom Q, using the N carrier gas and an N detector. Column temp. was 230° for I and 240° for II. Sensitivity threshold was 1 and 0.7 mg/mL, and recovery 74.5 and 79% for 2-20 mg I and 1-10 mg II/mL blood, resp.