Detail of "64719-49-9"

Reference

Potency of natural and artificial ultra-violet irradiation as determinants of plasma 25-hydroxyvitamin D in man

Potency of natural and artificial ultra-violet irradiation as determinants of plasma 25-hydroxyvitamin D in man. Stamp, T. C. B.; Haddad, J. G., Jr.; Twigg, C. A. (R. Natl. Orthop. Hosp., London, Engl.). Vitam. D: Biochem., Chem. Clin. Aspects Relat. Calcium Metab., Proc. Workshop Vitam. D, 3rd, 615-17. Edited by: Norman, Anthony W.; Schaefer, K.; Coburn, J. W. de Gruyter: Berlin, Ger. (English) 1977. CODEN: 36PEA2. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8, 2 In patients with various indications for vitamin D therapy or normal subjects who received long term treatment with vitamin D2 [50-14-6] or vitamin D3 [67-97-0] (at least 4 mo), there was a clear relation between vitamin D dosage and blood plasma 25-hydroxyvitamin D (I) [64719-49-9] levels. In subjects receiving 25-hydroxycholecalciferol (25-OHD3) [19356-17-3] (for at least 6 weeks) the relation between dosage and plasma I levels was less obvious. Within the dose range studied, 25-OHD3 was 8-13 times more potent than vitamin D on a wt. basis in producing equiv. plasma levels of I. In life guards in midsummer, plasma I was equiv. to that in patients receiving 8,000-10,000 IU vitamin D daily. Short term treatment with UV-light produced plasma I levels equiv. to 8,000-10,000 IU vitamin D. Again, 25-OHD3 was 10 times more potent than vitamin D. There appears to be constraints on the 25-hydroxylation of vitamin D, with only approx. 1/10 of the administered dose of vitamin D relative to 25-OHD3 appearing as plasma I.

Interactions of lead, calcium, vitamin D, and nutrition in lead-burdened children

Interactions of lead, calcium, vitamin D, and nutrition in lead-burdened children. Sorrell, Michael; Rosen, John F.; Roginsky, Martin (Dep. Pediatr., Montefiore Hosp. Med. Cent., Bronx, N. Y., USA). Arch. Environ. Health, 32(4), 160-4 (English) 1977. CODEN: AEHLAU. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Children with high (360 mg/dL) blood Pb concns. had lower intakes of vitamin D [1406-16-2] and Ca and lower serum levels of 25-hydroxyvitamin D [64719-49-9] than controls or children with minimally elevated blood Pb (30-59 mg/dL). Blood Pb and serum Ca were inversely correlated in all children. Possible mechanisms of interaction between Ca, vitamin D, and Pb are discussed.