Detail of "64742-88-7"

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Toxicology and carcinogenesis studies of Stoddard solvent IIC (CAS No

Toxicology and carcinogenesis studies of Stoddard solvent IIC (CAS No. 64742-88-7) in F344/N rats and B6C3F1 mice (inhalation studies). Chhabra, R. S.; Malarkey, D. E.; Bristol, D. W.; Bucher, J. R.; Hailey, J. R.; Haseman, J. K.; Herbert, R. A.; Maronpot, R. R.; Peckham, J. C.; Roycroft, J. H.; Smith, C. S.; Travlos, G. S.; Witt, K. L.; Chou, B. J.; Dill, J. A.; Grumbein, S. L.; Hayden, B. K.; Miller, R. A.; Renne, R. A.; Westerberg, R. B.; Hardisty, J. F.; Allison, N.; Cimon, K. J.; Willson, G.; Brecher, S.; Suttie, A.; Hanes, M. A.; Hill, G. D.; Nyska, A.; Wall, H. G.; Ching, S. V. (National Toxicology Program; National Toxicology Program, Research Triangle Park, NC 27709, USA). National Toxicology Program Technical Report Series, 519, 1-274 (English) 2004. CODEN: NTPSE3. ISSN: 0888-8051. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) White spirit (also called mineral spirit) is a complex mixt. of solvents derived from oil. The most widely used white spirit in the paint industry is called Stoddard solvent, and it is also used as a dry cleaning agent and as a solvent for cleaning and degreasing. The authors studied Stoddard solvent IIC to det. if it caused cancer in rats or mice. The authors exposed groups of 50 male and female rats and mice to air contg. Stoddard solvent six hours per day for two years. Male rats were exposed to 138, 550, or 1,100 mg of Stoddard solvent per cubic meter of air; female rats and male and female mice were exposed to 550, 1,100, or 2,200 mg/m3. Similar groups of 50 animals were exposed to clean air in the same inhalation chambers 6 h per day as the untreated control groups. Tissues from more than 40 sites were examd. for every animal. There were more deaths in male and female rats exposed to the highest concn. of Stoddard solvent than in other animal groups. There were no differences in survival of mice exposed to the solvent. Male rats exposed to Stoddard solvent IIC had higher rates of tumors of the adrenal gland, and female mice exposed to Stoddard solvent IIC had slightly increased rates of liver adenomas. The authors conclude that Stoddard solvent IIC caused cancer of the adrenal gland in male rats. An increase in liver tumors in female mice may have been related to exposure to Stoddard solvent IIC. There was no evidence that Stoddard solvent increased tumor rates in female rats or male mice.