Detail of "6480-68-8"

Reference

3-Quinolinecarboxylic acids

3-Quinolinecarboxylic acids. (Sterling Drug, Inc.Several substances are used for example 40034-42-2 and 61094-59-5 which are their cas registry numbers., USA). Japan. Kokai JP 51011777 30 Jan 1976 Showa, 10 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D401-04. PRIORITY: US 74-479627 17 Jun 1974. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) The title compds. I (R1 = alkyl) were prepd. by oxidn. of the acetylquinolines II (R1 = alkyl), which were obtained by cyclization of the [(pyridylanilino)methylene]acetoacetate III (R2 = alkyl) followed by alkylation of the acetylquinoline II (R1 = H). Thus, 22 g II (R1 = H), obtained by cyclization of III (R2 = Et), was heated with Et tosylate in DMF contg. K2CO3 on a steam bath for 15 min to give 18.0 g II (R1 = Et), which (3.0 g) was treated with Br in H2O contg. NaOH to give 2 g I (R1 = Et). .

3-Quinolinecarboxylic acid derivatives as antibacterials

3-Quinolinecarboxylic acid derivatives as antibacterials. (Warner-Lambert Co., USA). Jpn. Kokai Tokkyo Koho JP 61221174 A2 1 Oct 1986 Showa, 12 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: C07D215-56. ICS: C07D401-04; C07D451-04; C07D471-08; C07D487-04. ICI: C07D401-04, C07D207-00, C07D215-00; C07D471-08, C07D221-00. APPLICATION: JP 86-64267 24 Mar 1986. PRIORITY: US 85-716005 25 Mar 1985. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 The title compds. [I; R = (un)substituted NH2, R2 = C1-3 alkyl, C3-6 cycloalkyl; X = H, F], effective antibacterials (no data), are prepd. by reaction of esters II (R1 = C1-3 alkyl) with alkali metal nucleophile and subsequent reaction of the alkali salt with 31 mol equiv corresponding amine. Thus, 0.0048 mol Na was dissolved in EtOH-dioxane, H2O added, followed by 3.2 mmol II (R1 = Et, R2 = cyclopropyl, X = F) in dioxane to give 75% Na salt, which (0.47 mmol) was treated with 1.2 mol equiv N-ethyl-3-pyrrolidinemethylamine and further with DMF, then dil. 103054-57-5 is just another one chemical used in this study. HCl to give 88% I [R = 3-[(ethylamino)methyl]pyrrolidino, R2 = cyclopropyl, X = F]. .