Detail of "64855-91-0"

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Chemistry and pharmacology of arginine pyroglutamate

Chemistry and pharmacology of arginine pyroglutamate. Analysis of its effects on the CNS. Provenzano, P. M.; Brucato, A.; Gianguzza, S.; Coppola, A.; Orzalesi, G.; Selleri, R.; Innocenti, F.; Volpato, I. (Dep. Toxicol., Univ. Palermo, Palermo, Italy). Arzneim.-Forsch., 27(8), 1553-7 (English) 1977. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The effects of arginine pyroglutamate (I) [64855-91-0] on the central nervous system in rats were studied. I antagonized the general anesthesia produced by Na pentobarbital [57-33-0] even in the presence of medazepam [2898-12-6] and flurazepam [17617-23-1]. I also attenuated the decrease in locomotor behavior induced by pentobarbital and the benzodiazepines. I did not alter the sound discrimination capacity at fixed intervals nor did it influence the learning of a sound discrimination at varied intervals. Learning was moderately accelerated by I in temporal discrimination and conditioned avoidance response tests. Neither arginine nor pyroglutamate had any effect when given alone. Thus, I appears to block the effect of central nervous system depressants without affecting normal behavior.

Chemicopharmaceutic and pharmacodynamic characteristics of pyrglutargine

Chemicopharmaceutic and pharmacodynamic characteristics of pyrglutargine. Selleri, R.; Orzalesi, G.; Innocenti, F.; Volpato, I.; Bisagno, T. (Lab. Ric. Farmacobiol., Soc. Italo-Britannica, Calenzano, Italy). Boll. Chim. Farm., 116(12), 735-43 (Italian) 1977. CODEN: BCFAAI. ISSN: 0006-6648. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 6 Reaction of L-arginine with DL-pyroglutamic acid for a few min in boiling water, followed by evapn. of the solvent and crystn. of the product from 95% EtOH-H2O (7:3), yielded pyrglutargine (I) [64855-91-0], m. 216-17°, [a]25O +11.9° (c 7.00, H2O), cond. 54.4 S ′ mol-1. I is probably a pair of LL- and LD-diastereoisomers. IR, NMR, and mass spectra of I and of the 2 reactant amino acids are also illustrated and discussed. A review is given of previously published results on the pharmacol. of the compd. which showed it to affect the central nervous system, inhibiting the effects of neurodepressant drugs and facilitating the learning of some specialized behavior. The formulation of capsules and liq. solns. of I is also described.