Detail of "64872-76-0"

Reference

Compositions for reducing or preventing cellulite in mammalian skin containing conjugated linoleic acid and antifungal agent

Compositions for reducing or preventing cellulite in mammalian skin containing conjugated linoleic acid and antifungal agent. Sen, Anindita; Pieraccini, Peter; Lea-Currie, Yolanda Renee; Franklin, Dawn Marie (Zen-Bio, Inc., USA). PCT Int. Appl. WO 2003006009 A1 23 Jan 2003, 41 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, CZ, DE, DE, DK, DK, DM, DZ, EC, EE, EE, ES, FI, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K031-20. ICS: A61K031-415. APPLICATION: WO 2002-US11079 8 Apr 2002. PRIORITY: US 2001-PV304559 11 Jul 2001. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 62 Compns. and methods for preventing and/or treating cellulite in mammalian skin characterized by a s.c. accumulation of adipose tissue are provided. The skin care compn. comprises conjugated linoleic acid (CLA), an azole antifungal agent and a pharmaceutically acceptable carrier. In a particular embodiment, the compn. comprises effective amts. of 10-tans,12-cis-conjugated linoleic acid, ketoconazole and a dermatol. 9025-82-5 which is the cas registry number is also used here. 99592-32-2 and 64872-76-0 which are cas registry numbers of chemicals are mentioned. acceptable carrier. Prevention and/or treatment is accomplished by topically applying a compn. comprising safe and effective amts. of conjugated linoleic acid in combination with an imidazole antifungal agent. The compns. of the invention improve dermal appearance by promoting lipolysis and/or inhibiting de novo lipogenesis by adipocytes localized to targeted regions of mammalian skin. For example, a combination of CLA and ketoconazole was more effective in stimulating lipolysis than either compd. alone. ..