Reference

Studies on the effect of urapidil on the central nervous system and various organ functions in animal experiments

Studies on the effect of urapidil on the central nervous system and various organ functions in animal experiments. Schoetensack, W.; Eltze, M.; Goenne, S.; Kley, K. P.; Menge, H. G.; Mueller, H. (Forschungslab., Byk Gulden Lomberg Chem. Fabr. G.m.b.H., Constance, Ger.). Arzneim.-Forsch., 27(10), 1898-907 (German) 1977. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Urapidil-HCl (I) [64887-14-5] was screened in mice, rats, guinea pigs, and cats in a battery of tests relating to sportaneous behavior, reactive behavior, and autonomic and organ functions. I had a central sedative action in mice and rats at oral doses >10 mg/kg; for doses up to ~100 mg/kg, this sedation could be interrupted by external stimuli, and in this respect I differs from other centrally acting drugs such as chlorpromazine, diazepam, and clonidine. I seemed not to block central dopamine receptors, since it inhibited neither the conditioned avoidance reflex nor amphetamine-induced gnawing in mice and rats. I differed from tranquilizers such as diazepam in that it did not inhibit the spinal polysynaptic motor reflexes of the decerebrate cat. At <80 mg I/kg, orally, there were no hypotensive effects in rats, so that the obsd. changes in behavior were not due to acute changes in cardiovascular function. The antihistamine effect of I on the isolated guinea pig ileum was ~7% that of chlorpromazine. Further I had no anticholinergic activity.

Determination of adsorption of urapidil hydrochloride by syringe during intravenous injection via micro-pump

All Rights Reserved. Determination of adsorption of urapidil hydrochloride by syringe during intravenous injection via micro-pump. Du, Lifeng; Zhu, Lingling; Zhou, Quan (Department of Pharmacy, Taizhou First People's Hospital, Taizhou, Zhejiang Province 318020, Peop. Rep. China). Yiyao Daobao, 24(12), 1182 (Chinese) 2005 Yiyao Daobao Zazhishe. CODEN: YDIAAL. ISSN: 1004-0781. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) The method for the detn. of urapidil hydrochloride in injections was established by UV spectrophotometry with the detection wavelength of 268 nm, and whether there was adsorption of urapidil hydrochloride by syringe during i.There are some reagents like 64887-14-5 is used in this study.v. injection via micro-pump was studied. The calibration curve of urapidil hydrochloride had good linearity within the range of 3.2-11.2 mg/L (r = 0.9998). The av. recovery of urapidil hydrochloride was 99.5% with the relative std. deviation (RSD) of 1.7%, and the av. within-day precision and day-to-day precision were 1.3% and 2.2%, resp. There was no statistical difference in the content of urapidil hydrochloride during i.v. injection via micro-pump for 9 h. The results showed that there was no adsorption of urapidil hydrochloride by syringe during i.v. injection via micro-pump. .