Detail of "6490-42-2"

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Preparation, structure and cytotoxicity of cis-diammineplatinum(II) dinuclear complexes with 1-alkyluracil and imidate ligands

Preparation, structure and cytotoxicity of cis-diammineplatinum(II) dinuclear complexes with 1-alkyluracil and imidate ligands. Dohta, Yukifumi; Browning, C. Scott; Rekonen, Petri; Kodaka, Masato; Okada, Tomoko; Okamoto, Ken-ichi; Natale, Rosanne; Yip, Carol; Farrar, David H.; Okuno, Hiroaki (Biomolecules Department, National Institute of Bioscience and Human-Technology, Tsukuba, Ibaraki 305, Japan). Inorganica Chimica Acta, 263(1-2), 69-79 (English) 1997 Elsevier. CODEN: ICHAA3. ISSN: 0020-1693. DOCUMENT TYPE: Journal CA Section: 78 (Inorganic Chemicals and Reactions) Section cross-reference(s): 1, 75 Platinum dinuclear complexes with 1-alkyluracil, cis-[Pt2(EtU)2(NH3)4](NO3)2, cis-[Pt2(n-BuU)2(NH3)4](NO3)2, cis-[Pt2(NaphCH2U)2(NH3)4](NO3)2 (head-to-head, where U = uracil), and with imide ligands, cis-[Pt2(SI)2(NH3)4](NO3)2 (head-to-head), cis-[Pt2(DMGI)2(NH3)4](NO3)2 (head-to-head), cis-[Pt2(DMGI)2(NH3)4](NO3)2 (head-to-tail) and cis-[Pt2(EMGI)2(NH3)4](NO3)2 (head-to-head, where SI = succinimidate, EMGI = 3-ethyl-3-methylglutarimidate and DMGI = 3,3-dimethylglutarimidate) were synthesized, as well as platinum mononuclear complexes, cis-[PtCl(SI)(NH3)2] and cis-[Pt(SI)2(NH3)2]. The isomers of the dinuclear complexes (head-to-head and head-to-tail forms) were obtained sep. by fractional recrystns. Crystal structures of cis-[Pt2(SI)2(NH3)4](NO3)2 (head-to-head), cis-[Pt2(DMGI)2(NH3)4](NO3)2 (head-to-head) and cis-[Pt2(EMGI)2(NH3)4](NO3)2 (head-to-head) were detd. by x-ray diffraction anal. ([Pt2(SI)2(NH3)4](NO3)2×5/4H2O: orthorhombic, space group Pnma, R = 0.074; [Pt2(DMGI)2(NH3)4](NO3)2: triclinic, space group P1, R = 0.036; [Pt2(EMGI)2(NH3)4](NO3)2: triclinic, space group P1, R = 0.031). Cytotoxic activity was evaluated by the IC50 value using mouse sarcoma S-180 cells. Most head-to-head complexes are considerably active, while the corresponding head-to-tail analogs are inactive.Some commonly used reagents like 6490-42-2 is used in this experiment. The active complexes, in general, release ligands in saline at 37°, and a relation between hydrophobicity of the complexes and the IC50 value was shown. .