CAS No.65-22-5,4-Pyridinecarboxaldehyde,3-hydroxy-5-(hydroxymethyl)-2-methyl-, hydrochloride (1:1) Suppliers,MSDS download

Detail of "65-22-5"

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CAS Number:

65-22-5

Name:

4-Pyridinecarboxaldehyde,3-hydroxy-5-(hydroxymethyl)-2-methyl-, hydrochloride (1:1)

Superlist Name:

Pyridoxal hydrochloride

Molecular Structure:

Formula:

C₈H₉NO₃^.HCl

Molecular Weight:

203.64

Synonyms:

4-Pyridinecarboxaldehyde,3-hydroxy-5-(hydroxymethyl)-2-methyl-, hydrochloride (9CI);Pyridoxal,hydrochloride (7CI,8CI);2-Methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridinehydrochloride;3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehydehydrochloride;3-Hydroxy-5-hydroxymethyl-2-methylisonicotinaldehyde hydrochloride;

EINECS:

200-602-5

Melting Point:

173 °C (dec.)(lit.)

Boiling Point:

412.8 °C at 760 mmHg

Flash Point:

203.5 °C

Appearance:

White to off-white crystalline powder

Hazard Symbols:

Risk Codes:

20/21/22-36/37/38

Safety:

24/25-22-36-26 Details

Reference

Drug-induced changes in serum alkaline phosphatase and alanine aminotransferase activities not related to hepatic injuries: Drug-induced changes in serum alkaline phosphatase and alanine aminotransferase activities not related to hepatic injuries. Balazs, T.; Farber, T. M.; Feuer, G. (Food Drug Adm., Washington, D. C., USA). Arch. Toxikol., (Suppl. 1, Toxicol. Aspects Food Saf.), 159-63 (English) 1978. CODEN: ATXKA8. ISSN: 0003-9446. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In dogs treated orally with phenobarbital [50-06-6], diphenylhydantoin [630-93-3], primidone [125-33-7], or polybrominated biphenyls, only phenobarbital increased serum alk. phosphatase [9001-78-9]. No histol. changes were obsd. in the liver of any of the treated dogs. Cefazolin [25953-19-9] was given s.c. to rats at 2 g/kg/day on days 1-18 and at 0.5 g/kg/day on days 19-32. Isoniazid [54-85-3] was given orally at 20 mg/kg/day for 33 days to a similar group. Half of each group received pyridoxal-HCl [65-22-5], s.c., at 0.2 mg/kg/day on days 1-18 and at 2 mg/kg/day on days 19-46. Serum alanine aminotransferase [9000-86-6] decreased in each group, but returned to normal on day 32 in rats dosed with the isoniazid-pyridoxal combination. Isoniazid is known to interfere with alanine aminotransferase activity by decreasing the availability of the coenzyme. The mechanism of cefazolin has not been elucidated.

Neurotoxic effects of pyridoxine and analogs in rats: Neurotoxic effects of pyridoxine and analogs in rats. Frater-Schroeder, M.; Alder, S.; Zbinden, G. (Inst. Toxicol. 62511-99-3 and 59050-80-5 are also occured in this study., Fed. Inst. Technol., Zurich, Switz.). Proc. Eur. Soc. Toxicol., 17(Predict. Chronic Toxic. Short Term Stud., Proc. Meet., 1975), 277-84 (English) 1976. CODEN: PESTD5. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 18 Pyridoxine-HCl (I-HCl) [58-56-0], 3 active vitamin B6 forms (pyridoxamine-2HCl [524-36-7], pyridoxal-HCl [65-22-5], and pyridoxol phosphate-HCl [62511-96-0]) and 7 synthetic I analogs were injected repeatedly into female rats. Only I and pyridoxol phosphate caused neuromuscular deficit as demonstrated with the rotating rod method, and histopathol. lesions of the sciatic nerve. From these studies the structural requirements and the lipid-water distribution coeff. necessary for the neurotoxic action of I analogs were established. Based on in vitro model reactions a possible biomechanism for the neurotoxic effect of I is proposed. .

Detail of "65-22-5"

4-Pyridinecarboxaldehyde,3-hydroxy-5-(hydroxymethyl)-2-methyl-, hydrochloride (1:1)

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Reference