Detail of "65-30-5"

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CAS Number:
65-30-5
Name:
NICOTINE SULFATE
Superlist Name:
Nicotine sulfate
Molecular Structure:
Formula:
C₂₀H₂₆N₄•O₄S
Molecular Weight:
418.56
Synonyms:
(s)-3-(1-methyl-2-pyrrolidinyl)pyridinesulfate(2:1);1-methyl-2-(3-pyridyl)-pyrrolidinsulfate;3-(1-methyl-2-pyrrolidinyl)-pyridin(s)-pyridinsulfate(2:1);ai3-02435;caswellno.597a;ent2,435;epapesticidechemicalcode056703;l-1-methyl-2-(3-pyridyl)-pyrrolidinesulfate
EINECS:
200-606-7
Density:
1.22
Boiling Point:
244.4 °C at 760 mmHg
Flash Point:
101.7 °C
Solubility:
Soluble in water
Appearance:
brown Viscous liquid
Hazard Symbols:
T+
Risk Codes:
24/25-26-36/37/38-63
Safety:
Poison by ingestion and skin contact. When heated to decomposition it emits very toxic fumes of SO_x and organic fumes. See also NICOTINE and SULFATES. Details
Transport Information:
UN 1658 6

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Sensitization by caerulein of guinea pig ileum to contractions by acetylcholine, histamine, 5-hydroxytryptamine and nicotine: Sensitization by caerulein of guinea pig ileum to contractions by acetylcholine, histamine, 5-hydroxytryptamine and nicotine. Fontaine, Jeanine; Famaey, Jean Pierre; Reuse, Jean (Sch. Med., Univ. Brussels, Brussels, Belg.). Naunyn-Schmiedeberg's Arch. Pharmacol., 302(1), 51-4 (English) 1978. CODEN: NSAPCC. ISSN: 0369-5565. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Low concns. of caerulein [17650-98-5] (0.63 and 1.25 mg/mL) increased the submaximal contractions of the guinea pig isolated ileum induced by acetylcholine [51-84-3], histamine-HCl [56-92-8], 5-hydroxytryptamine maleate [18525-25-2], nicotine sulfate [65-30-5], or elec. stimulation. These effects of the polypeptide were due partly to neuronal pathways (i.e., a ganglionic stimulation) and partly to a nonspecific muscular sensitization. At higher concns. of caerulein the effects of all the agonists were decreased. This seems related to the contractile effect of the peptide itself on the longitudinal muscle which interfers nonspecificially with the development of contractions induced by any other agonists.

An analysis of 5-HT hyperpolarization of sympathetic ganglion cells: An analysis of 5-HT hyperpolarization of sympathetic ganglion cells. Shirasawa, Yoshiaki; Koketsu, Kyozo (Tokyo Res. Lab., Kowa Co., Ltd., Tokyo, Japan). Jpn. J. Pharmacol., 28(1), 57-60 (English) 1978. CODEN: JJPAAZ. ISSN: 0021-5198. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 12 Bullfrog sympathetic ganglion cells treated with nicotine sulfate [65-30-5] were hyperpolarized after application of 5-hydroxytryptamine creatinine sulfate (I) [971-74-4]. This induced hyperpolarization, however, was not obsd. if prepns. were treated with D-tubocurarine before being treated with nicotine. When prepns. were treated with acetylcholine or carbamylcholine, which transiently depolarizes ganglion cells, hyperpolarization did take place. A similar effect was obsd. in the presence of Ringer's soln. if prepns. were pretreated with the K+-free Ringer's soln. Apparently, ganglion cells are hyperpolarized by the action of I when the Na+-pump of these cells is accelerated by accumulation of intracellular Na+, as the result of a transient depolarization or extracellular K+ deficiency.