Detail of > 65085-01-0
- CAS Number:
- 65085-01-0
- Name:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,(6R,7R)-
- Superlist Name:
- Cefmenoxime
- Formula:
- C16H17N9O5S3
- Molecular Structure:
![Molecular Structure of 65085-01-0 (5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,(6R,7R)-)](http://www.lookchem.com/300w/2010/0623/65085-01-0.jpg)
- Synonyms:
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,[6R-[6a,7b(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,(6R,7R)- (9CI);AB 50912;Cefmenoxime;SCE 1365;
- Molecular Weight:
- 511.5585
- EINECS:
- 278-299-4
- Density:
- 1.96 g/cm3
- Appearance:
- almost White or almost yellow crystalline powder
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Reference
- Third-generation cephalosporins: a critical evaluation
- Third-generation cephalosporins: a critical evaluation. Barriere, Steven L.; Flaherty, John F. (Coll. Pharm., Univ. Michigan, Ann Arbor, MI, USA). Clin. Pharm., 3(4), 351-73 (English) 1984. CODEN: CPHADV. ISSN: 0278-2677. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) Section cross-reference(s): 10 A review with 313 refs. of the pharmacol. of 6 third-generation cephalosporins: cefotaxime [63527-52-6], moxalactam [64952-97-2], cefoperazone [62893-19-0], ceftizoxime [68401-81-0], ceftriaxone [73384-59-5], and cefmenoxime [65085-01-0].
- Newer b-lactam antibiotics in the treatment of experimental Staphylococcus aureus endocarditis
- Newer b-lactam antibiotics in the treatment of experimental Staphylococcus aureus endocarditis. Dhawan, Vinod K.; Thadepalli, Haragopal; Maier, Michael K.; Nayyar, Manmohan; Bansal, Madhu B.; Chuah, See Kean (Dep. Med., Charles R. Drew Postgrad. Med. Sch., Los Angeles, CA, USA). J. Antimicrob. Chemother., 14(2), 165-9 (English) 1984. CODEN: JACHDX. ISSN: 0305-7453. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Antistaphylococcal activity of three b-lactam antibiotics, i.e. cefmenoxime [65085-01-0], cefotaxime [63527-52-6] and latamoxef (moxalactam) [64952-97-2] was compared with that of nafcillin [147-52-4] by studying cure rates of aortic valvular endocarditis caused by one of three clin. isolates of Staphylococcus aureus in New Zealand white male rabbits. The rabbits were randomly allocated to a control and four antibiotic treatment groups. Each animal except the controls received 60 mg/kg of one antibiotic i.m. twice daily for two weeks, beginning 24 h after induction of endocarditis. The aortic valve was sterilized in 11 of 15 (73%) animals treated with cefmenoxime, nine of 13 (69%) treated with cefotaxime, 11 of 13 (85%) treated with latamoxef and 12 of 15 (80%) treated with nafcillin. All nine animals in the control group developed aortic valvular vegetations with an av. of 2.4 ′ 109 cfu/g. The differences in sterility rates resulting from treatment with the four antibiotics were not statistically significant (P>0.70).
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