Reference

N-(2-Hydroxyethyl)nicotinamide nitrate ester for treatment of circulatory diseases

N-(2-Hydroxyethyl)nicotinamide nitrate ester for treatment of circulatory diseases. Nagano, Hiroyuki; Mori, Takashi; Takaku, Sakae; Matsunaga, Isao; Kujirai, Tatsuo; Ogasawara, Toshichika; Sugano, Shigeru; Shindo, Minoru (Chugai Pharmaceutical Co., Ltd., Japan). Japan. Kokai JP 53009323 27 Jan 1978 Showa, 10 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-455. APPLICATION: JP 76-82458 13 Jul 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) N-(2-hydroxyethyl)nicotinamide nitrate (I nitrate) [65141-46-0] or I salts are formulated for the treatment of circulatory disorders. For example, a typical formulation (tablet) consisted of I-HCl [65141-45-9] 10, lactose 44.5, corn starch 20, cryst. cellulose 25, and Mg stearate 0.5 mg.

Comparative effects of a new nicotinamide nitrate derivative, nicorandil (SG 75), with nifedipine and nitroglycerin on true collateral blood flow following an acute coronary occlusion in dogs

Comparative effects of a new nicotinamide nitrate derivative, nicorandil (SG 75), with nifedipine and nitroglycerin on true collateral blood flow following an acute coronary occlusion in dogs. Lamping, Kathryn A.; Gross, Garret J. (Dep. Pharmacol. Toxicol., Med. Coll. Wisconsin, Milwaukee, WI, USA). J. Cardiovasc. Pharmacol., 6(4), 601-8 (English) 1984. CODEN: JCPCDT. ISSN: 0160-2446. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of nicorandil (NC)(I) [65141-46-0], nifedipine (NF) [21829-25-4], and nitroglycerin (GTN) [55-63-0] on true collateral blood flow were studied following an acute occlusion of the left anterior descending coronary artery in anesthetized dogs. The effects of each drug on true collateral blood flow were detd. following 1 h of coronary occlusion with the radioactive microsphere technique and with an indirect index of collateral perfusion, retrograde pressure. NC (25 mg/kg/min, i.v.), NF (1.0 mg/kg/min, i.v.), and GTN (1.5 mg/kg/min, i.v.) infusions reduced mean arterial and left ventricular systolic pressures similarly (10-20 mm Hg). None of the drugs had any effect on true collateral blood flow in the presence of a decrease in aortic blood pressure. However, when aortic pressure was maintained by use of a cuff around the descending thoracic aorta, NC and NF increased collateral flow as measured by the microsphere technique as well as by retrograde pressure. In addn., NC produced a significant increase in subendocardial blood flow, which resulted in an increase in the endocardial-epicardial blood-flow ratio (endo/epi). GTN had no significant effect on any index of collateral function. These results indicate the importance of aortic pressure in detg. the effects of vasodilators on coronary collateral function. Furthermore, NC may have more desirable effects on collateral blood flow than NF or GTN when hypotension is minimized, since this was the only agent that selectively increased subendocardial blood flow.