Reference

Spectrophotometry of theophylline-7-acetic acid and theophylline

Spectrophotometry of theophylline-7-acetic acid and theophylline. Owen, James A.; Nakatsu, Kanji (Fac. Med., Queen's Univ., Kingston, Ont., Can.). Clin. Chem. (Winston-Salem, N. C.), 24(2), 367-8 (English) 1978. CODEN: CLCHAU. ISSN: 0009-9147. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) A spectrophotometric assay procedure is described for individually measuring theophylline-7-acetic acid (I) [652-37-9] and theophylline [58-55-9] in 2.0 mL of serum. Absorbance is a linear function of concn. over a range of 0.5-50.0 mg/L for I and 0.5-40 mg/L for theophylline. No endogenous or exogenous compds. were found that interfere with I detns. As with other spectrophotometric theophylline assays, theobromine and, to a slight extent, phenobarbital interfere with theophylline detns.

.beta

.beta.-Lactam antibiotics derived from nitrogen hetrocyclic acetic acids. 1. Penicillin derivatives. Edwards, M. L.; Bambury, R. E.; Ritter, H. W.Some commonly used reagents like 62031-80-5 and 652-37-9 are used in this experiment. (Merrell-Natl. Lab. Div., Richardson-Merrell Inc., Cincinnati, Ohio, USA). J. Med. Chem., 20(4), 560-3 (English) 1977. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 28 Hydroxy-substituted N heterocycles were reacted with chloroacetic acid or Et bromoacetate to give the title acids, which were coupled with 6-aminopenicillanic acid [551-16-6] to give 19 title penicillin derivs. Penicillin derivs. prepd. from 1,2-dihydro-2-oxopyridine-1-acetic acids, 1,4-dihydro-4-oxopyridine-1-acetic acids, and 1,2,3,4-tetrahydro-2,4-dioxopyrimidine-1-acetic acids were most active in tests against gram-neg. and gram-pos. bacteria in exptl. infections in mice. Derivs. I [56607-41-1], II [56601-06-0], and III [62031-89-4] had the greatest broad-spectrum activity against Staphylococcus aureus, Streptococcus pneumoniae, Salmonella schottmuelleri, and Escherichia coli. Substitution (alkyl, Cl, NO2, Ac, and CN) in the heterocyclic ring or alkyl or Ph substitution in the .alpha. position decreased activity of the derivs. against gram-neg. bacteria. .