Detail of "652-78-8"

Reference

Flavonoid-induced delay in the small intestinal transit: possible mechanism of action

Flavonoid-induced delay in the small intestinal transit: possible mechanism of action. Viswanathan, S.; Sambantham, P. Thirugnana; Bapna, J. S.; Kameswaran, L. (Inst. Pharmacol., Madras Med. Coll., Madras 600003, India). Arch. Int. Pharmacodyn. Ther., 270(1), 151-7 (English) 1984. CODEN: AIPTAK. ISSN: 0003-9780. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Three flavonoids viz: gossypin [652-78-8], epicatechin [490-46-0] and hydroxyethyl rutoside [67326-49-2] were evaluated for their effect on small intestinal transit in mice. All 3 flavonoids delayed the small intestinal transit in a dose-dependent manner. Naloxone, yohimbine, and phentolamine antagonized the inhibitory effect of flavonoids, while it was not altered by prazosin, propranolol, atropine, physostigmine, hexamethonium, pheniramine, or metiamide. Apparently, opiate and a-2 adrenergic receptors mediate the flavonoid-induced delay of small intestinal transit.

Protective effect of some bioflavonoids on the x-irradiation-induced increase in capillary permeability of rat intestine

Protective effect of some bioflavonoids on the x-irradiation-induced increase in capillary permeability of rat intestine. Parmar, N. S.; Ghosh, M. N. (Dep. Pharmacol., Jawaharlal Inst. Postgrad. Med. Educ. Res., Pondicherry, India). Indian J. Exp. Biol., 15(4), 311-13 (English) 1977. CODEN: IJEBA6. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8 The radioprotective effect of the bioflavonoids O-(.beta.-hydroxyethyl)-rutoside [23869-24-1], gossypin (I) [652-78-8] and citrus bioflavonoid compd. on the X-irradn.-induced increase in the capillary permeability of rat intestine was studied. All 3 compds. produced a dose dependent depression of the increased permeability, but I appeared to be more potent than the other 2 compds.