Detail of "6528-53-6"

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Preparation of fine W/O/W emulsion through membrane filtration of coarse W/O/W emulsion and disappearance of the inclusion of outer phase solution

Preparation of fine W/O/W emulsion through membrane filtration of coarse W/O/W emulsion and disappearance of the inclusion of outer phase solution. Shima, Motohiro; Kobayashi, Yohei; Fujii, Takao; Tanaka, Miyono; Kimura, Yukitaka; Adachi, Shuji; Matsuno, Ryuichi (Graduate School of Agriculture, Division of Food Science and Biotechnology, Kyoto University, Sakyo-ku, Kyoto, Kitashirakawaoiwake-cho 606-8502, Japan). Food Hydrocolloids, Volume Date 2004, 18(1), 61-70 (English) 2003 Elsevier Science B.V. CODEN: FOHYES. ISSN: 0268-005X. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) A water-in-oil-in-water (W/O/W) emulsion was prepd. as a carrier system for the daily uptake of a bioactive compd. (e.g., in functional foods) by using decaglycerol monolaurate and hexaglyceryl condensed ricinolate as hydrophilic and lipophilic surfactants, resp. 1,3,6,8-Pyrenetetrasulfonic acid tetrasodium salt (PTSA) was used as a hydrophilic model compd. of a bioactive substance. Membrane filtration of a coarse W/O/W emulsion prepd. with a rotor/stator homogenizer produced a fine emulsion which had a mean oil-droplet diam. of <1 mm. The emulsions were stable for 1 wk at 4°C. The encapsulation efficiency of PTSA was >90%. Microscopic observations revealed that the fluorescent material in the outer-phase soln. was included into the oil phase during rotor/stator homogenization. It was suggested that because the rotor/stator homogenizer was used to produce both O/W and W/O/W emulsions, some part of the outer phase soln. would be included in the oil phase during the second homogenization. The fluorescence shown in the oil droplets of the coarse W/O/W emulsion was diminished after membrane emulsification. This phenomenon suggested that the included outer-phase soln. was released to the outer-phase soln. from the interior of the W/O/W oil droplets during the membrane emulsification.

Blocker efflux through blocked pores

Blocker efflux through blocked pores. Ronan, Dawn; Sorde, Nathalie; Matile, Stefan (Department of Organic Chemistry, University of Geneva, Geneva, Switz.). Journal of Physical Organic Chemistry, 17(11), 978-982 (English) 2004 John Wiley & Sons Ltd. CODEN: JPOCEE. ISSN: 0894-3230. DOCUMENT TYPE: Journal CA Section: 6 (General Biochemistry) The objective of this paper is to clarify a frequent confusion that occurs with synthetic multifunctional pores: does mol. recognition by a synthetic pore exclude mol. translocation through the same pore. Evidence that this is not the case is provided with a set of competitive expts. using a rigid-rod b-barrel with internal histidine-arginine dyads as synthetic multifunctional pores (SMPs) as well as 8-hydroxypyrene-1,3,6-trisulfonate (HPTS) as a fluorescent and 1,3,6,8-pyrenetetrasulfonate (PTS) as a non-fluorescent blocker.Several substances with their cas registry numbers 6528-53-6 and 587869-99-6 may be metioned in this study. Direct evidence for the efflux of HPTS blockers through blocked SMPs is obtained by quenching of released HPTS with an externally added quencher. Blockage of blocker efflux through blocked pores was demonstrated by adding PTS as the opposing external blocker (KD = 3.3 mM). A Hill coeff. of n = 1.5 may indicate that binding of more than one PTS blocker is necessary to inhibit the efflux of HPTS blockers. Supported by structural information on blockage and selectivity from biol. potassium channels, blocker efflux through blocked pores is discussed as being implicated in selectivity. .