Detail of "6541-19-1"

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Synthesis and cytotoxicity evaluation of pyridin[2,3-f]indole-2,4,9-trione and benz[f]indole-2,4,9-trione derivatives

Synthesis and cytotoxicity evaluation of pyridin[2,3-f]indole-2,4,9-trione and benz[f]indole-2,4,9-trione derivatives. Lee, Hyun-Jung; Park, So-Young; Kim, Jin Sung; Song, Hyun Min; Suh, Myung-Eun; Lee, Chong-Ock (College of Pharmacy, Department of Medicinal Chemistry, Ewha Woman's University, Seoul 120-750, S. Korea).Chemicals with cas numbers 648928-19-2 and 6541-19-1 also play role. Bioorganic & Medicinal Chemistry, 11(22), 4791-4796 (English) 2003 Elsevier Ltd. CODEN: BMECEP. ISSN: 0968-0896. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 27 3-Ethoxycarbonyl-3-methyl-1N-substituted-2,3-dihydro-pyridin[2,3-f]indo le-2,4,9-trione and 3-ethoxycarbonyl-3-methyl-N-substituted-2,3-dihydro-benz[f]indole-2,4,9 -trione derivs. were synthesized from 7-chloro-6-(1,1-diethoxycarbonyl-ethyl)-5,8-quinolinedione and 2-chloro-3-(1,1-diethoxycarbonyl-ethyl)-1,4-naphthoquinone, resp., using a variety of alkyl- and arylamines. The cytotoxic activities of the synthesized compds. were evaluated by a Sulforhodamine B (SRB) assay against the following tumor cell lines: A459 (human non-small cell lung), SK-OV-3 (human ovarian), SK-MEL-2 (human melanoma), XF498 (human CNS), and HCT 15 (human colon). Almost all the derivs. mentioned above had a more potent cytotoxic effect against SK-OV-3 than etoposide. In particular, 3-ethoxycarbonyl-3-methyl-N-(4-aminophenyl)-2,3-dihydro-benz[f]indole -2,4,9-trione (I) exhibited greater activity against all the tumor cell lines, and its cytotoxic effect against SK-OV-3 was esp. higher than doxorubicin. .

Method for preparation of pyridophenazinedione derivatives as anticancer agents

Method for preparation of pyridophenazinedione derivatives as anticancer agents. Park, Se Yeong; Suh, Myung Eun (S. Korea ). Repub. Korean Kongkae Taeho Kongbo KR 2003012289 A 12 Feb 2003,No pp. given (Korean). (Korea, Republic Of). CODEN: KRXXA7. CLASS: ICM: C07D487-04. APPLICATION: KR 2001-46263 31 Jul 2001. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Provided are pyridophenazinedione derivs. which have stronger anticancer activity than quinone compds. and a method thereof and anticancer agents contg. them. The pyridophenazinedione deriv. is represented by the formula(1), wherein R1 is -H, R2 is -H, -CH3, R3 is -H, -CH3, -C2H5, -Cl and -Br. It is manufd. by the steps of: reaction of 6,7-dichloro-5,8-quinolinedione and arom. amine to prep. 6-arylamino-7-chloro-5,8-quinolinedione deriv.; reacting of the 6-arylamino-7-chloro-5,8-quinolinedione deriv. with NaN3 using DMF as a solvent to prep. the pyridophenazinedione deriv. 6541-19-1 is just another one chemical used in this study. by cyclization reaction in a mol. .