Detail of "6552-63-2"

CAS Number:
6552-63-2
Name:
2-Propen-1-one,1-(4-chlorophenyl)-3-(4-methoxyphenyl)-
Molecular Structure:
Formula:
C₁₆H₁₃ClO₂
Molecular Weight:
272.73
Synonyms:
Chalcone,4'-chloro-4-methoxy- (6CI,7CI,8CI);1-(4-Chlorophenyl)-3-(4-methoxyphenyl)-2-Propen-1-one;4'-Chloro-4-methoxychalcone;
Density:
1.207 g/cm³
Boiling Point:
434.8 °C at 760 mmHg
Flash Point:
176.1 °C

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Structure-activity relation of substituted flavonoids: Structure-activity relation of substituted flavonoids. II. The antifungal activity of chalcones and similar heterocyclic compounds. Hsu, K. K.; Lo, M. S.; Chen, F. C. (Sch. Pharm., Natl.There are some reagents like 61864-66-2 is used in this study. Taiwan Univ., Taipei, Taiwan). T'ai-wan K'o Hsueh, 29(2), 35-9 (Chinese) 1975. CODEN: TKHSAU. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Chalcones (I), heterocyclic acrylophenones (II, R = heterocyclic group), heterocyclic phenyl ketoethylenes (III, R1 = heterocyclic group), and R1COC:CR (IV) were tested for their antimicrobial activity. Of 10 chalcones tested, V (I; R = 4-Me, R1 = 2-OH) [16635-14-6], VI (I; R = 4-Me, R1 = 3-OH) [61864-69-5] and VII (I; R = H, R1 = 2-OH and 5-Me) [6552-63-2] were the most active, and VI had a broader antimicrobial activity than V. VIII (II; R = 2-furyl, R1 = 2-OH and 5-Me) [40664-94-6] was the most active among 11 heterocyclic acrylophenones examd. Of 4 heterocyclic phenyl ketoethylenes, IX (III; R = 4-Br, R1 = 2-furyl) [61864-70-8] appeared to be more active than other compds. tested. .alpha.-(2-Furoyl)-.beta.-2-methyl-6-pyridyl)ethylene (IV; R = 2-Me and 6-pyridyl, R1 = furyl) [61864-68-4] was more effective than .alpha.-(2-thienoyl)-.beta.-(2-furyl)ethylene (IV; R = 2-furyl, R1 = 2-thienyl) [13343-96-9]. .