Detail of "6590-96-1"

Reference

(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors with Broad Antiproliferative Activity against Tumor Cells

(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors with Broad Antiproliferative Activity against Tumor Cells. Ho, Chih Y.; Ludovici, Donald W.; Maharoof, Umar S. M.; Mei, Jay; Sechler, Jan L.; Tuman, Robert W.; Strobel, Eric D.; Andraka, Laura; Yen, Hwa-Kwo; Leo, Gregory; Li, Jian; Almond, Harold; Lu, Hong; DeVine, Ann; Tominovich, Rose M.; Baker, Judith; Emanuel, Stuart; Gruninger, Robert H.; Middleton, Steven A.; Johnson, Dana L.; Galemmo, Robert A., Jr. (Oncology Research Team, High Throughput Chemistry Team, Molecular Design and Informatics Team, Analytical Research Team, Johnson Johnson Pharmaceutical Research and Development L.L.C., Spring House, PA 19477, USA). Journal of Medicinal Chemistry, 48(26), 8163-8173 (English) 2005 American Chemical Society. 872872-09-8 and 6590-96-1 which are cas registry numbers of chemicals are mentioned. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 28 A series of (6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines has been optimized to preserve both potent kinase inhibition activity against the angiogenesis target, the receptor tyrosine kinase of Platelet-Derived Growth Factor-BB (PDGF-BB), and to improve the broad tumor cell antiproliferative activity of these compds. This series culminates in the discovery of 17 (JNJ-10198409), a compd. with anti-PDGFR-b kinase activity (IC50 = 0.0042 mM) and potent antiproliferative activity in six of eight human tumor cell lines (IC50 < 0.033 mM). .