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CAS No.: | 66-81-9 |
---|---|
Name: | Actidione |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C15H23NO4 |
Molecular Weight: | 281.352 |
Synonyms: | Glutarimide, 3-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-(7CI,8CI);Naramycin A (6CI);3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide;Acti-Aid;Acti-dione;Actidion;Cicloheximide;Cycloheximide;LDN 97549;NM-MCD 80;NSC 185;Naramycin;Naramycin Microcapsule D 80;Naramycin NM-MCU 80;TZA;U 4527;b-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide; |
EINECS: | 200-636-0 |
Density: | 1.136 g/cm3 |
Melting Point: | 111-116 °C |
Boiling Point: | 491.8 °C at 760 mmHg |
Flash Point: | 251.2 °C |
Solubility: | 2.1 g/100 mL (2 °C) in water |
Appearance: | Off-white to light tan powder |
Hazard Symbols: | Xn, T, N, T+ |
Risk Codes: | 22-68-61-51/53-28 |
Safety: | 53-45-61 |
Transport Information: | UN 2811 6.1/PG 1 |
PSA: | 83.47000 |
LogP: | 1.37030 |
Product Name: Actidione (CAS NO.66-81-9)
Molecular Formula: C15H23NO4
Molecular Weight: 281.35g/mol
Mol File: 66-81-9.mol
EINECS: 200-636-0
Appearance: Off-white to light tan powder
Melting Point: 107-114 ºC
Boiling point: 491.8 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 251.2 °C
Density: 1.136 g/cm3
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, alkali.
Index of Refraction: 1.498
Molar Refractivity: 72.66 cm3
Molar Volume: 247.5 cm3
Surface Tension: 39.9 dyne/cm
Enthalpy of Vaporization: 87.39 kJ/mol
Vapour Pressure: 9.81E-12 mmHg at 25°C
XLogP3-AA: 0.5
H-Bond Donor: 2
H-Bond Acceptor: 4
Structure Descriptors of Actidione (CAS NO.66-81-9):
IUPAC Name: 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
Canonical SMILES: CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C
Isomeric SMILES: C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C
InChI: InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChIKey: YPHMISFOHDHNIV-FSZOTQKASA-N
Product Categories: scellaneous; Antibiotic Explorer; Antifungal; Signalling
1. | skn-rbt 5 mg/24H rns | TXCYAC Toxicology. 14 (1949),117. | ||
2. | skn-rbt 1%/24H MOD | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB-274-414 . | ||
3. | dni-hmn:oth 100 mg/L | BBACAQ Biochimica et Biophysica Acta. 696 (1982),15. | ||
4. | dni-hmn:oth 300 nmol/L | CNREA8 Cancer Research. 44 (1984),2421. | ||
5. | orl-rat LD50:2 mg/kg | UPJOH* “Compounds Available for Fundamental Research, 2 (6),(1971), | ||
6. | ipr-rat LD50:3700 µg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 136 (1962),400. | ||
7. | scu-rat LD50:2500 µg/kg | ANTCAO Antibiotics and Chemotherapy. 10 (1960),682. | ||
8. | ivn-rat LD50:2 mg/kg | ANTCAO Antibiotics and Chemotherapy. 10 (1960),682. | ||
9. | orl-mus LD50:133 mg/kg | UPJOH* “Compounds Available for Fundamental Research, 2 (6),(1971), | ||
10. | ipr-mus LD50:100 mg/kg | CNCRA6 Cancer Chemotherapy Reports. 30 (1963),9. | ||
EPA Extremely Hazardous Substances List. EPA Genetic Toxicology Program.
A poison by ingestion, subcutaneous, intraperitoneal and intravenous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A skin irritant. A pesticide. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes Xn,T,N,T+
Risk Statements 22-68-61-51/53-28
R22:Harmful if swallowed.
R68:Possible risk of irreversible effects.
R60:May impair fertility.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R28:Very toxic if swallowed.
Safety Statements 53-45-61
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR UN 2811 6.1/PG
WGK Germany 3
RTECS MA4375000
HazardClass 6.1(a)
PackingGroup II
Actidione , its CAS NO. is 66-81-9, the synonyms are Cycloheximide ; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide ; [1S-[1alpha(S*),3alpha,5beta]]-4-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione .