Detail of "66-81-9"

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CAS Number:
66-81-9
Name:
Actidione
Molecular Structure:
Formula:
C₁₅H₂₃NO₄
Molecular Weight:
281.39
Synonyms:
Glutarimide, 3-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-(7CI,8CI);Naramycin A (6CI);3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide;Acti-Aid;Acti-dione;Actidion;Cicloheximide;Cycloheximide;LDN 97549;NM-MCD 80;NSC 185;Naramycin;Naramycin Microcapsule D 80;Naramycin NM-MCU 80;TZA;U 4527;b-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide;
EINECS:
200-636-0
Density:
1.136 g/cm³
Melting Point:
111-116 °C
Boiling Point:
491.8 °C at 760 mmHg
Flash Point:
251.2 °C
Solubility:
2.1 g/100 mL (2 °C) in water
Appearance:
Off-white to light tan powder
Hazard Symbols:
Xn, T, N, T+
Risk Codes:
22-68-61-51/53-28
Safety:
53-45-61 Details
Transport Information:
UN 2811 6.1/PG 1

Effect of cycloheximide on DNA replication: Effect of cycloheximide on DNA replication. III. Autoradiography of lysed cells. Diment, A. V.; Blinova, M. I. (Lab. Physiol. Cell Cycles, Inst. Cytol., Leningrad, USSR). Tsitologiya, 20(7), 819-22 (Russian) 1978. CODEN: TSITAQ. ISSN: 0041-3771. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) DNA fiber autoradiog. of lysed L cells showed that cycloheximide [66-81-9] (0.5 mg/mL) blocked the elongation (normal rate of 0.4 m/min and av. size of replicon of 21 mm) of thymidine-3H-labeled regions in replicating units. Problems in explaining the exptl. data are discussed.

Cycloheximide-induced mitotic delay in Physarum polycephalum: Cycloheximide-induced mitotic delay in Physarum polycephalum. Scheffey, Carl; Wille, J. J. (Dep. Biophys. Theor. Biol., Univ. Chicago, Chicago, Ill., USA). Exp. Cell Res., 113(2), 259-62 (English) 1978. CODEN: ECREAL. ISSN: 0014-4827. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Cycloheximide (I) [66-81-9] pulses applied to Physarum polycephalum surface plasmodia delayed mitosis. Pulses applied in G2 caused a delay of mitosis which was linearly dependent on the phase in the cell cycle at which the pulse was applied. A 30 min pulse of 10 mg I/mL starting in G2 at time t after mitosis induced an excess delay (delay in excess of pulse duration) of the next mitosis of (0.55)t-1.3. h. The excess delays induced by 7 h pulses during G2 were at most 1 h larger. Pulses applied less than 30 min before mitosis induced only small delays.