Reference

Protective effect of a mixture of radioprotective substances (AET and mexamine) on the hemopoietic stem cells of mice

Protective effect of a mixture of radioprotective substances (AET and mexamine) on the hemopoietic stem cells of mice. Vacek, A.; Rotkovska, D.; Sikulova, J.; Dikovenko, E. A.; Barkaja, V. S. (Inst. Biophys., Czech. Acad. Sci., Brno, Czech.). Strahlentherapie, 154(6), 424-9 (English) 1978. CODEN: STRAAA. ISSN: 0039-2073. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8 AET (2-aminoethylisothiouronium bromide-HBr) [56-10-0] (150 mg/kg, i.p.) and mexamine (I) [66-83-1] (25 mg/kg, s.c.), injected consecutively, had a protective effect for 5 h on the hemopoietic stem cells and on the survival of mice irradiated with a LD of x-rays. The post-irradn. decrease in the wt. of the small intestine was smaller in treated animals than in controls. After administration of AET and I, muscle O tension decreased to 10% of the initial value; but the radioprotective effect lasted longer than the tissue hypoxia. I may induced AET transport to radiosensitive tissues.

Radioprotectant effect of AET and mexamine on dehydrogenases of the pentose phosphate cycle

Radioprotectant effect of AET and mexamine on dehydrogenases of the pentose phosphate cycle. Gorelik, Yu. Ya.; Rusanov, A. M.; Krutovskikh, G. N.; Gornaeva, G. F. (Cent. Res. Inst. Roentgenol. Radiol., Leningrad, USSR). Radiobiologiya, 17(6), 897-900 (Russian) 1977. CODEN: RADOA8. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8 Radiation induced inhibition of pentose phosphate cycle dehydrogenases in erythrocytes was prevented by mexamine [66-83-1] (20 and 50 mg/kg, i.p.) in guinea pigs and rats and by S,b-aminoethylisothiuronium-HBr [56-10-0] (150 mg/kg, i.p.) in guinea pigs. When the animals were protected with mexamine or b-aminoethylisothiuronium-HBr, enzyme activity increased by 13.9 and 18.6%, resp., on the 4th day after irradn. In mexamine protected rats pentose phosphate cycle dehydrogenase activity increased by 65%, compared with unprotected animals, on the 8th day after exposure of 800 R. Glucose 6-phosphate dehydrogenase [9001-40-5] activity in the bone marrow of rats on the 4th and 6th days after irradn. with 600 R was twice as high in treated rats as in controls.