Detail of "66-97-7"

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CAS Number:
66-97-7
Name:
7H-Furo[3,2-g][1]benzopyran-7-one
Superlist Name:
Psoralen
Molecular Structure:
Formula:
C₁₁H₆O₃
Molecular Weight:
186.17
Synonyms:
Furocoumarin(6CI);2-Propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, d-lactone;6,7-Furanocoumarin;Ficusin;Furo[2',3':7,6]coumarin;Furo[4',5':6,7]coumarin;NSC 404562;Psoralen;Psoralene;
EINECS:
200-639-7
Density:
1.389 g/cm³
Melting Point:
160-162 °C
Boiling Point:
362.6 °C at 760 mmHg
Flash Point:
173.1 °C
Appearance:
Crystalline solid
Hazard Symbols:
Xi
Risk Codes:
22-36/37/38
Safety:
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Effect of chemical mutagens on the yield and quality of herbage of Heracleum sosnowskyi Manden: Effect of chemical mutagens on the yield and quality of herbage of Heracleum sosnowskyi Manden. Budyak, V. T. (Velikoluk. S-kh. Inst., Velikoluki, USSR). Rastit. Resur., 20(3), 337-40 (Russian) 1984. CODEN: RRESA8. ISSN: 0033-9946. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemical Bioregulators) Soaking the title seed in 0.01% dimethyl sulfate [77-78-1] gave in M1 1% of plants free of the photosensitizing furocoumarins angelicin [523-50-2], xanthotoxin [298-81-7], and psoralen [66-97-7]. Nitrosomethylurea [684-93-5] at 0.010% increased crude protein and fiber, and almost doubled carotene in the herbage. Diethyl sulfate [64-67-5] at 0.05% also induced a no. of interesting mutations.

Psoralen photosensitization of L 1210 leukemia cells: an approach to a new combined therapy: Psoralen photosensitization of L 1210 leukemia cells: an approach to a new combined therapy. Carlassare, F.; Baccichetti, F.; Bordin, F.; Anselmo, L. (Inst. Pharm. Chem., Padua Univ., Padua, Italy). Z. Naturforsch., C: Biosci., 33C(1-2), 92-5 (English) 1978. CODEN: ZNCBDA. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Psoralen (I) [66-97-7] photosensitization of L 1210 cells had a strong effect on DNA and RNA syntheses and this result appears connected with the I photobinding to DNA. Protein synthesis was less sensitive and its inhibition seems due to a different photochem. interaction, very likely to the I photobinding to RNA. A combined therapy using cyclophosphamide [50-18-0] and L 1210 cells I-photoinactivated was performed after the leukemia transplant, showing a significant decrease in mortality, even in comparison with the simple treatment with the alkylating drug.