Detail of "66142-81-2"

Reference

4-Bromo-2,5-dimethoxyphenethylamine: identification of a new street drug

4-Bromo-2,5-dimethoxyphenethylamine: identification of a new street drug. Ragan, F. A., Jr.; Hite, S. A.; Samuels, M. S.; Garey, R. E. (Med. Cent., Louisiana State Univ., New Orleans, LA 70112, USA). J. Anal. Toxicol., 9(2), 91-3 (English) 1985. CODEN: JATOD3. ISSN: 0146-4760. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The identification of 4-bromo-2,5-dimethoxyphenethylamine (I) [66142-81-2] as a street drug is described. NMR, UV, and mass spectral data used in the identification of I are presented.

Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human

Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human. Carmo, Helena; Hengstler, Jan G.; de Boer, Douwe; Ringel, Michael; Remiao, Fernando; Carvalho, Felix; Fernandes, Eduarda; dos Reys, Lesseps A.; Oesch, Franz; Bastos, Maria de Lourdes (REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Oporto 4050-047, Port.). Toxicology, 206(1), 75-89 (English) 2005 Elsevier B.V. CODEN: TXCYAC. ISSN: 0300-483X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 4 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive designer drug of abuse that is sold under the street names "Venus", "Bromo", "Erox", "XTC" or "Nexus". Concern has been raised because only little is known about its toxicity and metab. in humans. In the present study the authors incubated 2C-B with human, monkey, dog, rabbit, rat and mouse hepatocytes to identify the metabolites formed and to det. possible toxic effects as evidenced by an ATP assay. Our data allow construction of the main metabolic pathways of 2C-B. Oxidative deamination results in the 2-(4-bromo-2,5-dimethoxyphenyl)-ethanol (BDMPE) and 4-bromo-2,5-dimethoxyphenylacetic acid (BDMPAA) metabolites. Addnl., 4-bromo-2,5-dimethoxybenzoic acid (BDMBA) can be produced also by oxidative deamination. Further metab. of BDMPE and BDMPAA may occur by demethylation. Alternatively, the later metabolites can be generated by demethylation of 2C-B followed by oxidative deamination. Two remarkable interspecies differences in metab. of 2C-B were obsd. 66142-81-2 which is the cas registry number of one of substances is just one of reagents here.: (i) a hitherto unknown metabolite, 4-bromo-2,5-dimethoxy-phenol (BDMP), was identified after incubation only with mouse hepatocytes; (ii) 2-(4-bromo-2-hydroxy-5-methoxyphenyl)-ethanol (B-2-HMPE) was produced by hepatocytes from human, monkey and rabbit but not by dog, rat and mouse. Comparing the toxic effects of 2C-B between hepatocytes of the six examd. species the authors obsd. only minor interspecies differences. However, large interindividual differences in susceptibility of hepatocytes from three human donors were obsd. .