Detail of "66148-78-5"

CAS Number:
66148-78-5
Name:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[[2-carboxy-2-(3-thienyl)acetyl]amino]-6-methoxy-3,3-dimethyl-7-oxo-,(2S,5R,6S)-
Superlist Name:
Temocillin
Molecular Structure:
Formula:
C₁₆H₁₈N₂O₇S₂
Molecular Weight:
414.45
Synonyms:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[(carboxy-3-thienylacetyl)amino]-6-methoxy-3,3-dimethyl-7-oxo-,(2S,5R,6S)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[(carboxy-3-thienylacetyl)amino]-6-methoxy-3,3-dimethyl-7-oxo-, [2S-(2a,5a,6a)]-;AB 17421;Temocillin;(2S,5R,6S)-6-{[Carboxy(3-thienyl)acetyl]amino}-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylato;
EINECS:
266-184-1
Density:
1.6 g/cm³
Boiling Point:
761.9 °C at 760 mmHg
Flash Point:
414.6 °C

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Temocillin (BRL 17421) activity in experimental Klebsiella pneumoniae pyelonephritis in rats: Temocillin (BRL 17421) activity in experimental Klebsiella pneumoniae pyelonephritis in rats. Keratzopoulos, D.; Ritzerfeld, W. (Inst. Hyg., Univ. Muenster, Muenster, Fed. Rep. Ger.). Chemioterapia, 2(5, Suppl.: Mediterr. Congr. Chemother., Proc., 3rd, 1982), 143-4 (English) 1983. CODEN: CHEMEV. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In rats with exptl. pyelonephritis due to Klebsiella pneumoniae, temocillin (I) [66148-78-5] (25 or 50 mg/kg/day, i.m., for 3 days) was highly effective even at the lower dose in reducing infection. I appears to be very promising for clin. use in cases of human upper urinary tract infections caused by the major Gram-neg. pathogens.

Biological inactivation by feces of antimicrobial drugs applicable in selective decontamination of the digestive tract: Biological inactivation by feces of antimicrobial drugs applicable in selective decontamination of the digestive tract. Veringa, Etel M.; Van der Waaij, D. (Dep. Med. Microbiol., Univ. Hosp., Groningen, Neth.). J. Antimicrob. Chemother., 14(6), 605-12 (English) 1984. CODEN: JACHDX. ISSN: 0305-7453. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Nalidixic acid [389-08-2], colistin [1066-17-7], neomycin [1404-04-2], tobramycin [32986-56-4], temocillin [66148-78-5], trimethoprim [738-70-5], and aztreonam [78110-38-0] were inactivated in vitro when sep. mixed with fecal suspensions from healthy volunteers. This biol. inactivation by intestinal contents occurred rapidly with all 7 antimicrobial drugs, though not all to the same extent. Such inactivation may explain why some unabsorbed or minimally absorbed drugs require higher oral doses than others to achieve eradication of gram-neg. bacteria from the digestive tract by selective decontamination.