Reference

Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris

Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris. Klock, J.; Ikeno, H.; Ohmori, K.; Nishikawa, T.; Vollhardt, J.; Schehlmann, V. (R & D, DSM Nutritional Products Ltd, Basel, Switz.). International Journal of Cosmetic Science, 27(3), 171-176 (English) 2005 Blackwell Publishing Ltd. CODEN: IJCMDW. ISSN: 0142-5463. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) Section cross-reference(s): 1 Acne vulgaris is the most common inflammatory skin disorder and jeopardizes seriously the facial impression of a person. Development of acne involves a complex relation among several causes. Treatment and prevention success can be archived by affecting the main contributors pos. 66170-10-3 which is the cas registry number is also used here. like Proprionibacterium acnes or lipid oxidn. leading to inflammatory reactions and follicular keratinization. Vitamin C tends to break down in cosmetic formulations resulting in a brownish discoloration. Sodium ascorbyl phosphate (SAP) represents a stable precursor of vitamin C that ensures a const. delivery of vitamin C into the skin. The authors were able to show that 1% SAP has a strong antimicrobial effect with a log redn. of 5 after 8 h on P. acnes in a time-kill study. In a human in vivo study with 20 subjects, an SAP O/W formulation significantly prevents the UVA-induced sebum oxidn. up to 40%. Finally, the authors performed an open in vivo study with 60 subjects with a 5% SAP lotion over 12 wk. The efficacy ranked as excellent and good of SAP was 76.9%, which was superior compared with a widely prescribed acne treatment. In conclusion, these data show that SAP is efficient in the prevention and treatment of acne vulgaris. SAP can be used in a non-antibiotic and effective treatment or co-treatment of acne with no side effects, which makes it particularly attractive for cosmetic purposes. .