Detail of "6622-92-0"

MSDS Download
CAS Number:
6622-92-0
Name:
4(3H)-Pyrimidinone,2,6-dimethyl-
Superlist Name:
2,4-Dimethyl-6-hydroxypyrimidine
Molecular Structure:
Formula:
C₆H₈N₂O
Molecular Weight:
124.14
Synonyms:
4(1H)-Pyrimidinone,2,6-dimethyl- (8CI,9CI);2,6-Dimethyl-4-hydroxypyrimidine;2,6-Dimethyl-4-pyrimidinol;2,6-Dimethylpyrimidin-4-one;4-Hydroxy-2,6-dimethylpyrimidine;6-Hydroxy-2,4-dimethylpyrimidine;NSC 54507;
EINECS:
229-577-9
Density:
1.17 g/cm³
Melting Point:
198-200 °C
Boiling Point:
201.9 °C at 760 mmHg
Flash Point:
75.9 °C
Appearance:
white crystalline needles
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-36 Details

Display：

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Preparation of pyrimidine derivatives as angiotensin II receptor antagonists: Preparation of pyrimidine derivatives as angiotensin II receptor antagonists..Several substances are used for example 6622-92-0 which is its cas registry number. Shidara, Naganori; Katano, Kiyoaki; Ogino, Hiroko; Nagura, Jun; Osada, Naomi; Konno, Fukio; Machinami, Tomoya; Tsuruoka, Takashi (Meiji Seika Kaisha, Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 04120072 A2 21 Apr 1992 Heisei, 10 pp. (Japan). CODEN: JKXXAF. CLASS: ICM: C07D403-12. ICS: A61K031-505; C07D239-34; C07D239-36. APPLICATION: JP 90-239101 11 Sep 1990. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 The title compds.Several reagents such as 6622-92-0 is used here. [I; A = (un)substituted pyrimidinyloxy, -amino, -sulfonyl, etc.; B = CO2H, (un)substituted alkoxycarbonyl, (un)substituted tetrazolyl] are prepd. 2,6-Dimethyl-(3H)-4-pyrimidinone was condensed with 4-(bromomethyl)-2-(1-trityl-1H-tetrazol-5-yl)biphenyl in DMF contg. NaH followed by detritylation to give I [A = 2,4-dimethyl-6-pyrimidinyloxy, B = 1H-tetrazol-5-yl]. In an in vitro test using the aorta from rats, this at 10-5 M showed 100% inhibition of angiotensin II-induced contraction. Capsules, tablets, etc., contg. I are formulated. ..

Preparation of pyrimidine derivatives as angiotensin II receptor antagonists: Preparation of pyrimidine derivatives as angiotensin II receptor antagonists..Several substances are used for example 6622-92-0 which is its cas registry number. Shidara, Naganori; Katano, Kiyoaki; Ogino, Hiroko; Nagura, Jun; Osada, Naomi; Konno, Fukio; Machinami, Tomoya; Tsuruoka, Takashi (Meiji Seika Kaisha, Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 04120072 A2 21 Apr 1992 Heisei, 10 pp. (Japan). CODEN: JKXXAF. CLASS: ICM: C07D403-12. ICS: A61K031-505; C07D239-34; C07D239-36. APPLICATION: JP 90-239101 11 Sep 1990. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 The title compds.Several reagents such as 6622-92-0 is used here. [I; A = (un)substituted pyrimidinyloxy, -amino, -sulfonyl, etc.; B = CO2H, (un)substituted alkoxycarbonyl, (un)substituted tetrazolyl] are prepd. 2,6-Dimethyl-(3H)-4-pyrimidinone was condensed with 4-(bromomethyl)-2-(1-trityl-1H-tetrazol-5-yl)biphenyl in DMF contg. NaH followed by detritylation to give I [A = 2,4-dimethyl-6-pyrimidinyloxy, B = 1H-tetrazol-5-yl]. In an in vitro test using the aorta from rats, this at 10-5 M showed 100% inhibition of angiotensin II-induced contraction. Capsules, tablets, etc., contg. I are formulated. ..