Detail of "6635-24-1"

Reference

Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles

Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles. Walsh, John S.; Wang, Regina; Bagan, Edward; Wang, C. C.; Wislocki, Peter; Miwa, Gerald T. (Dep. Anim. Drug Metabol., Merck Sharp and Dohme Res. Lab., Rahway, NJ 07065, USA). J. Med. Chem., 30(1), 150-6 (English) 1987. CODEN: JMCMAR. ISSN: 0022-2623. 6635-24-1 and 104575-32-8 are cas registry numbers of chemicals which are used as reagents here. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Two approaches have been used to develop nonmutagenic 5-nitroimidazoles, both of which are based on knowledge of the likely mechanisms by which this class of compds. cause mutagenicity. The first approach involves incorporating readily oxidizable gallate derivs. into the mol. In one case, a very weakly mutagenic active antitrichomonal agent was obtained. The second approach involved incorporating a substituent at the C-4 position of the ring. This generally resulted in a large redn. in mutagenicity and a lowering of antitrichomonal activity in vitro. In certain cases, however, mutagenicity was dramatically reduced while moderate antitrichomonal activity was retained. For example, 1,2-dimethyl-4-(2-hydroxyethyl)-5-nitroimidazole (I) showed good antitrichomonal activity in vitro (ED50 = 2 mg/kg) while possessing only 4% of the mutagenicity of metronidazole. .

Denture- and tooth-bleaching compositions containing peroxy compounds and gallate esters

Denture- and tooth-bleaching compositions containing peroxy compounds and gallate esters. Iwazumi, Masanori; Nagai, Tadashi; Nagata, Takashi (Mitsui Chemicals Inc., Japan). Jpn. Kokai Tokkyo Koho JP 2003049196 A2 21 Feb 2003, 5 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: C11D007-54. ICS: C11D007-18; C11D007-26; C11D007-32; A61L002-16. APPLICATION: JP 2001-235408 2 Aug 2001. DOCUMENT TYPE: Patent CA Section: 62 (Essential Oils and Cosmetics) Section cross-reference(s): 26, 63 The compns. for bleaching of artificial, vital, and non-vital teeth, contain peroxy compds. and gallate esters I [R1-R3 = amino, lower alkyl, lower alkenyl, aminoalkyl, (substituted) phenyl; R4 = H, lower alkyl, lower alkenyl, catechin skeleton, gallocatechin skeleton, glucose skeleton] as bleach activators. A soln. 6635-24-1 which is the cas registry number is also used here. contg. There are some commonly used reagents like 6635-24-1 in this article. 0.32 mM alizarin (having structure similar to black tea pigment) was bleached with 3.0 mM gallic acid Me ester acetate and 30 mM H2O2 to a bleaching rate of ~90% within 120 min. ..