Detail of "66532-85-2"

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Propacetamol augments inhibition of platelet function by diclofenac in volunteers

Propacetamol augments inhibition of platelet function by diclofenac in volunteers. Munsterhjelm, E.Several substances are used for example 66532-85-2 and 15307-86-5 which are their cas registry numbers.; Niemi, T. T.; Syrjaelae, M. T.; Ylikorkala, O.; Rosenberg, P. H. (Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki FIN-0029, Finland). British Journal of Anaesthesia, 91(3), 357-362 (English) 2003 Oxford University Press. CODEN: BJANAD. ISSN: 0007-0912. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Acetaminophen (paracetamol) enhances the analgesic effect of non-steroidal antiinflammatory drugs (NSAIDs). Acetaminophen is a weak inhibitor of cyclooxygenase (COX), and its combination with an NSAID may augment COX inhibition-related side effects. Ten healthy male volunteers (21-30 yr) were given diclofenac 1.1 mg kg-1 alone, a combination of propacetamol 30 mg kg-1 (which is hydrolyzed to 50% acetaminophen) and diclofenac 1.1 mg kg-1 or placebo i.v. in a double blind, crossover study. Platelet function was assessed at 5 min, 90 min and 22-24 h by photometric aggregometry, platelet function analyzer (PFA-100?) and by measuring the release of thromboxane B2 (TxB2). Analgesia was assessed with the cold pressor test. Platelet aggregation induced with arachidonic acid was fully inhibited by both diclofenac alone and the combination at the end of the 30-min drug infusion. Propacetamol augmented the inhibition by diclofenac at 90 min (P=0.014). At 22-24 h, platelet function had fully recovered. TxB2 release was inhibited by the combination of propacetamol and diclofenac at 90 min in comparison with diclofenac alone (P=0.027). PFA-100? detected no difference in platelet function between these two groups. No analgesic effect was detected with the cold pressor test. Thus, the combination of propacetamol and diclofenac inhibits platelet function more than diclofenac alone. This should be considered when assessing the risk of surgical bleeding. .

Occupational contact dermatitis from propacetamol

Occupational contact dermatitis from propacetamol. Szczurko, C.; Dompmartin, A.; Michel, M.; Castel, B.; Leroy, D. ( Department of Dermatology of Caen, Fr.). Contact Dermatitis, 35(5), 299-301 (English) 1996 Munksgaard. CODEN: CODEDG. ISSN: 0105-1873. DOCUMENT TYPE: Journal CA Section: 59 (Air Pollution and Industrial Hygiene) Section cross-reference(s): 4, 63 Four cases of contact sensitization (dermatitis) from exposure to propacetamol are reported. Lesions on the hands, forearms, crease of the elbows, and neck were obsd.; all were sensitized to multiple allergens and 2 were atopic. Patch tests to Pro-Dafalgan and propacetamol were pos.; sodium citrate and paracetamol were neg. These cases were similar to those published for the first time by A. 66532-85-2 is the cas registry number of certain chemical which is used as reagents here. Barbaud, et.al., 1995. The only allergen was propacetamol; patch tests with diethlyglycine and paracetamol were neg. Propacetamol chlorhydrate is composed of a complex paracetamol-diethylglycine, which probably acts like a hapten capable of inducing cutaneous allergy. It is an occupational allergy affecting nurses who work in surgical departments or post-anesthesia recovery rooms, where high doses of analgesics are widely used. Patients were not allergic to oral paracetamol. Despite usual precautions, the mixt. of propacetamol chlorhydrate and solvent leaks onto nurses' hands, suggesting that health care workers handling propacetamol chlorhydrate should wear gloves. .