Detail of "66535-86-2"

Reference

Return of fertility in the rat and the hamster after pregnancy termination induced by DL 717-IT

Return of fertility in the rat and the hamster after pregnancy termination induced by DL 717-IT. Galliani, Giulio; Assandri, Alessandro; Barone, Domenico; Gallico, Licia (Lepetit Res. Lab., Milan 20158, Italy). IRCS Med. Sci., 12(5), 433-4 (English) 1984. CODEN: IMSCE2. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Pregnancy termination in rats and hamsters with the isoquinoline deriv., DL 717-IT (I) [66535-86-2], had no effect on subsequent fertility. The estrous cycle reappeared in all I-treated animals and most conceived on mating. Rats treated with I delived at the appropriate time and litter size and sex ratio of young were similar to controls. Lactation was also unaffected by previous I treatment. Evidently, pregnancy termination induced by I is not accompanied by any alteration of reproductive capability.

Lack of affinity of the contragestational agents DL 111-IT and DL 717-IT for receptors of the major neurotransmitters

Lack of affinity of the contragestational agents DL 111-IT and DL 717-IT for receptors of the major neurotransmitters. Barone, Domenico; Assandri, Alessandro; Galliani, Giulio (Lepetit Res. Lab., Milan 20158, Italy). IRCS Med. Sci., 12(5), 442-3 (English) 1984. CODEN: IMSCE2. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The potential antifertility agents DL 111IT [69095-83-6] and DL 717IT (I) [66535-86-2] showed no affinity for rat brain synaptosomal membrane neurotransmitter receptors, as indicated by their inability to displace a no. of tritiated ligands. Although these compds. and (or) their metabolites were reported to barely cross the blood-brain barrier, their lack of central nervous system activity is probably related to a failure to bind to brain receptors rather than to their poor ability to reach the receptors.