Detail of "6682-26-4"

CAS Number:
6682-26-4
Name:
1-Propanamine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, N-oxide
Molecular Structure:
Formula:
C20H21 N O
Molecular Weight:
0
Synonyms:
5H-Dibenzo[a,d]cycloheptene-D5,g-propylamine, N,N-dimethyl-, N-oxide (7CI,8CI); CyclobenzaprineN-oxide
Melting Point:
106-108°C

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Identification of cyclobenzaprine-10,11-epoxides in rat urine and after incubation with rat liver microsomes: Identification of cyclobenzaprine-10,11-epoxides in rat urine and after incubation with rat liver microsomes. Belvedere, G.; Frigerio, A.; Pantarotto, C.; Rovei, V. (Ist. Ric. Farmacol. "Mario Negri", Milan, Italy). Adv. Mass Spectrom. Biochem. Med., 2, 101-18 (English) 1977. 6682-26-4 and 303-50-4 are also in the experiment. CODEN: AMSMDB. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 26 After injection of cyclobenzaprine-HCl (I) [6202-23-9] (200 gm, i.p.) to rats, the following metabolites were isolated in the urine: cyclobenzaprine-10,11-epoxide [58256-08-9], cyclobenzaprine N-oxide [6682-26-4], demethylcyclobenzaprine [303-50-4], hydroxycyclobenzaprine [59920-63-7], demethylhydroxycyclobenzaprine [59920-64-8], and hydroxycyclobenzaprine N-oxide [59920-65-9]. After incubation of I with the rat liver microsomal fraction, the metabolites were: cyclobenzaprine-10,11-epoxide, cyclobenzaprine N-oxide, demethylcyclobenzaprine, and 10,11-epoxycyclobenzaprine N-oxide [58728-71-5]. .