Detail of "6686-02-8"

Reference

Pharmacological effect of dipeptides on ovarian and uterine weights in immature mice

Pharmacological effect of dipeptides on ovarian and uterine weights in immature mice. Pitkow, Howard S.; Willner, Richard; Udell, Samuel; Davis, Robert H. (Dep. Physiol. Sci., Pennsylvania Coll. Podiatr. Med., Philadelphia, Pa., USA). IRCS Med. Sci.: Libr. Compend., 5(8), 378 (English) 1977. CODEN: IRLCDZ. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 3 In female CF-1 mice, L-tryptophan-L-phenylalanine [6686-02-8] (2 mg/kg) administered in 6 s.c. injections ove 3 days, increased uterine wt. compared to controls. Higher doses (75 mg/kg) also caused an insignificant increase in ovarian wt. L-tryptophan-L-isoleucine [64339-42-0] (75 mg/kg) increased both uterus and ovary wts. although the effect on uterine wt. was not statistically significant.

Method and apparatus for generating and screening specific-binding peptides

Method and apparatus for generating and screening specific-binding peptides. Venton, Duane L. (Receptor Laboratories, Inc., USA). PCT Int. Appl. WO 9112331 A1 22 Aug 1991, 32 pp. DESIGNATED STATES: W: CA, JP, US; RW: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE. (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C12P021-06. ICS: B01D061-14; G01N033-53; C12Q001-00; C07K001-12. APPLICATION: WO 91-US891 13 Feb 1991.Several reagents with their cas registry numbers 108322-11-8 and 6686-02-8 are used here. PRIORITY: US 90-480865 14 Feb 1990. DOCUMENT TYPE: Patent CA Section: 9 (Biochemical Methods) A large population of peptides are generated and screened for the presence of peptides which bind a particular macromol. complex with high affinity. The method further allows favored net synthesis of analyzable quantities of such peptides by using as the "trap" a macromol. or macromol. complex for which binding of the peptide is desired. Schematic diagrams of an app. for performing the method are included. Proteolytic enzymes (both forward and reverse reactions) are used in generation of the multiplicity of peptides. The generated peptides are in fluid communication with the macromol. or macromol. complex via e.g. a semipermeable membrane. Generation of peptides by a variety of proteases is described, as is identification of peptides which bind to e.g. renin or collagenase IV. .