Reference

Evidence for a noncovalent intermolecular interaction of opiates with thiamin

Evidence for a noncovalent intermolecular interaction of opiates with thiamin. Misra, A. L.; Vadlamani, N. L.; Pontani, R. B. (Test. Res. Lab., New York State Off. Drug Abuse Serv., Brooklyn, N. Y., USA). Res. Commun. Chem. Pathol. Pharmacol., 18(3), 581-4 (English) 1977. CODEN: RCOCB8. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Opiate agonists and antagonists formed reversible mol. complexes with thiamin-HCl (I) [67-03-8]. The absorption max. of these complexes were at wavelengths longer than those of the individual components and their intensities depended on the concn. and nature of the opiate component. The possible implications of such an interaction are discussed.

Study of the bioavailability of thiamin hydrochloride in fluid systems

Study of the bioavailability of thiamin hydrochloride in fluid systems. Popovici, Adriana; Lungu, Veronica; Papp, I.; Rogosca, Maria (Lab. Teh. Farm., Inst. Med. Farm., Targu-Mures, Rom.). Farmacia (Bucharest), 26(1), 17-24 (Romanian) 1978. CODEN: FRMBAZ. ISSN: 0014-8237. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The transfer rate const. of thiamin-HCl (I) [67-03-8] in presence of tween, water-sol. vitamins and auxiliary substances was detd. in oral liq. vitamin prepns. The transfer rate const. of I was decreased in presence of ascorbic acid [50-81-7], Tween 80 [9005-65-6] up to 1%, cysteine-HCl [52-89-1] 0.15, sorbitol [50-70-4] 10, and saccharose [57-50-1] 30%, unchanged in presence of vitamin B6 [8059-24-3], and nipagin [99-76-3] 0.1%, and increased in presence of vitamin B2 [83-88-5] and glucose [50-99-7] 30%. The difference in the exptl. vs. calcd. values are discussed.