Detail of "67-21-0"

Reference

Effects of phenylalanine and analogs of methionine and phenylalanine on the composition of wool and mouse hair

Effects of phenylalanine and analogs of methionine and phenylalanine on the composition of wool and mouse hair. Reis, P. J.; Gillespie, J. M. (Div. Anim. Prod., CSIRO, Blacktown 2148, Australia). Aust. J. Biol. Sci., 38(2), 151-63 (English) 1985. CODEN: AJBSAM. ISSN: 0004-9417. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Section cross-reference(s): 40 Administration of the methionine analog methoxinine [2598-48-3] to sheep substantially changed the compn. of wool; in addn., wool fibers were weakened and the staple crimp frequency was reduced for a prolonged period. The proportions of high tyrosine [60-18-4] proteins were reduced by 40-45% whereas the high-S proteins were usually slightly increased. The content of high-tyrosine proteins in wool was still depressed in most sheep 70 days after dosing with methoxinine. These expts. supported a previous finding that the cystine content of wool and its crimp frequency are not causally related. Ethionine [67-21-0], another methionine analog, did not consistently change the compn. of wool. In some sheep there was no change in the proportions of high-tyrosine proteins following administration of ethionine, even though weak wool was produced. This result, together with the lack of assocn. between the content of high-tyrosine proteins and the strength of wool fibers in sheep given methoxinine plus methionine, indicates that a redn. of the high-tyrosine proteins is not a prerequisite for the prodn. of weak wool. Neither a 3-fold increase in the phenylalanine [63-91-2] intake by mice nor the administration of 3 analogs of phenylalanine 4-fluoro-DL-phenylalanine [51-65-0], 4-chloro-DL-phenylalanine [7424-00-2], and b-(2-thienyl)-DL-alanine [2021-58-1] to sheep altered the compn. of hair or wool. Fluorophenylalanine was incorporated into all the constituent proteins of wool to the extent of ~2% of phenylalanine residues. The other analogs studied could not be detected in wool.

Effect of DL-ethionine on the concentration and synthesis of uridine diphosphate sugars in the liver of rat

Effect of DL-ethionine on the concentration and synthesis of uridine diphosphate sugars in the liver of rat. Tosheva, R.; Zhivkov, V. (Inst. Gen. Comp. Pathol., Sofia, Bulg.). Int. J. Biochem. 56-65-5 and 63-39-8 which are cas registry numbers are also used here., 7(12), 615-18 (English) 1976. CODEN: IJBOBV. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) The i.p. administration of DL-ethionine [67-21-0] to female rats slightly lowered the liver concn. of UDP-glucose [133-89-1] after 4 and 8 h, and the UDP-N-acetylglucosamine [528-04-1] level showed no change and an increase, resp. In contrast, ethionine caused a marked decrease in the UDP-glucuronic acid [2616-64-0] level at the 4 h and its complete disappearance after 8 h. The rates of syntheses of UDP-glucose and UDP-N-acetylglucosamine 4 h after ethionine were only about 33% of normal rates, and UDP-glucuronic acid formation was about 5% of normal. Ethionine produced small increases in liver uridine nucleotide levels, but sharply decreased the concns. of adenine nucleotides. .