Reference

Studies on the sensibilizing and stabilizing effect of macromolecules on plant-protecting suspensions

Studies on the sensibilizing and stabilizing effect of macromolecules on plant-protecting suspensions. Bozzay, J.; Rusznak, I.; Zilahy, T. (Dep. Org. Chem. Technol., Tech. Univ., Budapest, Hung.). Proc. Conf. Appl. Chem., Unit Oper. Processes, 3rd, 537-41. Magy. Kem. Egyesulete: Budapest, Hung. (English) 1977. CODEN: 38VGAI. DOCUMENT TYPE: Conference CA Section: 5 (Agrochemicals) Furazolidone (I) [67-45-8] stability was increased by the addn. of PVP [9003-39-8] (av. mol. wt. 25,000) in a concn.-dependent manner. The min. stabilizing concn. was ￡10-2g PVP/L. The opposite, or sensibilizing effect was also discussed.

Effect of nitrofurans on the membrane apparatus of coccus bacteria

Effect of nitrofurans on the membrane apparatus of coccus bacteria. Kutsemako, R. T.; Kulyash, Yu. V.; Rudzit, E. A.; Ermachenko, V. A.; Simakova, I. M.; Kharat'yan, E. F.; Lukoyanova, M. A. (A. N. Bach Inst. Biochem., Moscow, USSR). Prikl. Biokhim. Mikrobiol., 20(6), 798-803, 2 plates (Russian) 1984. CODEN: PBMIAK. ISSN: 0555-1099. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 10 Secondary membrane effects of nitrofurans [furazolidone (I) [67-45-8], solafur [21287-44-5], furazolin [139-91-3], and furacrylin [10048-74-5]] were examd. on the membrane app. of the cocci Staphylococcus aureus 209-p and Micrococcus lysodeikticus at subbacteriostatic concns. (5 mg/mL). Nitrofurans had a damaging effect on the membrane structure of the microorganisms under growing conditions. Solafur was the most active probably due to its water soly., and thus penetration into the bacterial cells. Nitrofurans inhibited the biosynthesis of membrane proteins, among them cytochromes, and decreased the activities of NADH [9079-67-8], malate- [9001-64-3], and lactate dehydrogenase [9001-60-9]. However, no cell death was obsd, the bacteria being adapted to a lower energy level. In a related study, cells grown in the presence of solafur, I, and furacrylin the cocci showed cytol. changes.