Detail of "67-96-9"

Reference

Effect of ambient heat stress on body development of rats and effect of drugs on heat stress survival

Effect of ambient heat stress on body development of rats and effect of drugs on heat stress survival.Some chemicals with cas registry numbers like 1255-49-8 and 62-90-8 are also used. Sulman, F. G. (Sch. Pharm., Hebrew Univ. Jerusalem, Jerusalem, Israel). Isr. J. Med. Sci., 12(9), 1134-5 (English) 1976. CODEN: IJMDAI. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 2 Daily s.c. injections of the following 5 of the 19 drugs tested decreased the mortality of rats at an ambient temp. of 37-38.degree.: Paracetamol (acetaminophen) [103-90-2] (1-5 mg/kg/day), BOL-148 (p-2-bromolysergic diethylamide) [478-84-2] (0.01-0.1 mg/kg/day), Pacatol (mepazine) [60-89-9] (0.01-0.1 mg/kg/day) Diandron (dihydroepiandrosterone) [53-43-0] (5-50 mg/kg/day), Hytakerol (dihydrotachysterol) [67-96-9] (0.1-0.5 mg/kg/day). .

The effects of various diphosphonates on a rat model of cardiac calciphylaxis

The effects of various diphosphonates on a rat model of cardiac calciphylaxis. Rosenblum, I. Y.; Black, H. E.; Ferrell, J. F. (Miami Val. Lab., Procter and Gamble Co., Cincinnati, Ohio, USA). Calcif. Tissue Res., 23(2), 151-9 (English) 1977. CODEN: CATRBZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 14 Seven diphosphonate analogs were tested for their effects on myocardial and cardiovascular degeneration and calcification in an exptl. model of cardiac calciphylaxis. A single oral dose of dihydrotachysterol (DHT) [67-96-9] administered to rats induced myocardial and vascular degeneration, focal myocarditis and vasculitis, and myocardial and vascular mineralization. The results demonstrated a considerable variation among the various diphosphonates in their ability to block the pathol. changes obsd. in this model. Ethane-1-hydroxy-1,1-diphosphonic acid (EHDP) [2809-21-4] was the most effective diphosphonate in reducing myocardial and vascular degeneration and calcification, whereas diphosphonates such as ethane-1-amino-1,1-diphosphonic acid (EADP) [15049-85-1] and hydroxymethylene diphosphonic acid (HMDP) [15468-10-7] had little or no effect compared to saline controls. For those diphosphonates which were effective, e.g., EHDP, the tissue-protective effects were obsd. whether the rats were treated with drug prior to the administration of DHT, or whether drug treatment commenced after DHT administration. The results are discussed in terms of the known biol. properties of the diphosphonate drugs.