Detail of "672-87-7"

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Effects of catecholamine depleting drugs and d-amphetamine on self-stimulation of the substantia nigra and locus coeruleus

Effects of catecholamine depleting drugs and d-amphetamine on self-stimulation of the substantia nigra and locus coeruleus. Cooper, Barrett R.; Konkol, Richard J.; Breese, George R. (Biol. Sci. Res. Cent., Univ. North Carolina Sch. Med., Chapel Hill, N. C., USA). J. Pharmacol. Exp. Ther., 204(3), 592-605 (English) 1978. CODEN: JPETAB. ISSN: 0022-3565. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) 6-Hydroxydopamine treatments which preferentially depleted either norepinephrine [51-41-2] or dopamine [51-61-6] were used to define the importance of these transmitter systems in the behavioral alterations produced by catecholamine synthesis inhibitors and d-amphetamine sulfate [51-63-8] on self-stimulation of the locus coeruleus and substantia nigra. After chronic redn. of brain dopamine, an acute depression of self-stimulation of both the locus coeruleus and substantia nigra occurred. Preferential depletion of norepinephrine with 6-hydroxydopamine did not result in a significant decrease in self-stimulation of locus coeruleus or substantia nigra. However, a dose of l-a-methyltyrosine [672-87-7] which had no effect in control rats or in rats with brain norepinephrine depleted caused a significant redn. in responding at both electrode placements in animals depleted of brain dopamine. Administration of U-14624 [14901-16-7] affected neither the substantia nigra nor locus coeruleus self-stimulation, even though it produced an addnl. 70% depletion of norepinephrine. When d-amphetamine sulfate was given to 6-hydroxydopamine-treated rats, the facilitation of self-stimulation produced by this compd. was significantly attenuated in rats with prior depletion of brain dopamine. Depletion of brain norepinephrine did not affect the actions of d-amphetamine on self-stimulation. In other expts., the actions of d-amphetamine to increase self-stimulation of animals pretreated with reserpine were antagonized by a-methyltryosine but not by U-14,624. Results suggest that drugs can alter self-stimulation of a site in brain anatomically assocd. with noradrenergic neural pathways and self-stimulation of a site primarily assocd. with dopaminergic pathways in a similar manner. These data also provided evidence for the involvement of dopamine fibers in the pharmacol. actions of d-amphetamine, reserpine [50-55-5], and a-methyltyrosine.

Biochemical aspects of the central nervous system stimulating and euphoria producing effect of ethanol

Biochemical aspects of the central nervous system stimulating and euphoria producing effect of ethanol. Engel, Jorgen (Farmakol. Inst, Goeteborgs Univ., Goeteborg, Swed.). Laekartidningen, 71(10), 954-5 (Swedish) 1974. CODEN: LAKAA3. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1 Normal human volunteers were given tablets of 0.125 g .alpha.-methyltyrosine [672-87-7] and 5 mL EtOH [64-17-5] every 10 min for a period of 40 min during a social affair, and controls were given EtOH and placebo. .alpha.-Methyl tyrosine produced a sensation of fatigue, a feeling of disquiet, and decreased intellectual endeavors. It is concluded that EtOH has a stimulating effect on catecholamine formation and euphoria, effects which could be counteracted by .alpha.-methyltyrosine, an inhibitor of catecholamine formation. The catecholamines apparently are involved in the effects of EtOH. Thus, drugs which interfere with the neurotransmission of catecholamines maybe used in the treatment of narcomania, including alcoholism.