CAS No.67219-55-0,Cytidine,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy- Suppliers,MSDS download

Detail of "67219-55-0"

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CAS Number:

67219-55-0

Name:

Cytidine,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-

Superlist Name:

5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

Molecular Structure:

Formula:

C₃₇H₃₅N₃O₇

Molecular Weight:

633.70

Synonyms:

Cytidine,N-benzoyl-5'-O-[a,a-bis(p-methoxyphenyl)benzyl]-2'-deoxy- (7CI);N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine;

EINECS:

266-605-9

Density:

1.274 g/cm³

Melting Point:

119 °C

Appearance:

Off-white powder

Hazard Symbols:

Risk Codes:

Safety:

36/37 Details

Reference

Solid-phase synthesis of oligodeoxyribonucleoside methylphosphonates: Solid-phase synthesis of oligodeoxyribonucleoside methylphosphonates. Miller, Paul S.; Reddy, M. Parameswara; Murakami, Akira; Blake, Kathleen R.; Lin, Shwu Bin; Agris, Cheryl H. (Sch. Hyg. Public Health, Johns Hopkins Univ., Baltimore, MD 21205, USA). Biochemistry, 25(18), 5092-7 (English) 1986. CODEN: BICHAW. ISSN: 0006-2960. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Oligodeoxyribonucleoside methylphosphonates d-Np(Np)nN, (n = 6-13) were readily prepd. on insol. polystyrene supports by use of protected 5'-(dimethoxytrityl)deoxyribonucleoside 3'-(methylphosphonic imidazolides) as synthetic intermediates. The imidazolides were prepd. in situ by reaction of protected 5'-(dimethoxytrityl)deoxyribonucleosides with methylphosphonic bis(imidazolide). The condensation reaction was accelerated by the presence of tetrazole, which appeared to act an an acid catalyst. The half-life for dimer formation on the polystyrene support was 5 min, and the reaction was 95% complete after 60 min. Although similar kinetics were obsd. when controlled pore glass was used as the support, the extent of the reaction was ￡ 78%, even after prolonged incubation. In order to simplify purifn. and sequence anal. of the oligomer, the 5'-terminal nucleoside unit was linked via a phosphodiester bond. This linkage was introduced by either an o-chlorophenyl phosphotriester method or a cyanoethyl phosphoramidite method. The latter procedure simplified the deprotection step, since the cyanoethyl group was readily cleaved by ethylenediamine, which also removed the base protecting group and cleaved the oligomer from the support. 103562-81-8 and 67219-55-0 which are cas registry numbers of substances are two of reagents here. The singly charged oligomers were easily purified by affinity chromatog. on DEAE-cellulose. The chain lengths of the oligomers were confirmed after 5'-end labeling with polynucleotide kinase by partial hydrolysis of the methylphosphonate linkages with 1 M aq. piperidine followed by polyacrylamide gel electrophoresis of the hydrolyzate. The positions of purine and pyrimidine bases were confirmed by treatment of 5'-end labeled oligomers with acid and hydrazine. .

Detail of "67219-55-0"

Cytidine,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-

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CAS No.67219-55-0 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

CAS No.67219-55-0 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

CAS No.67219-55-0 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

CAS No.67219-55-0 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

CAS No.67219-55-0 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

CAS No.67219-55-0 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

CAS No.67219-55-0 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

CAS No.67219-55-0 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

CAS No.67219-55-0 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

CAS No.67219-55-0 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

CAS No.67219-55-0 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

Reference